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EC number: 259-160-7
CAS number: 54423-67-5
Rats were exposed nose-only to vapours of vinyl neononaoate in a GLP,
O.E.C.D. 412 Testing Guideline 28 -day repeated dose study with
neurtoxicity screen. Primary findings of adverse effects occured in male
rats at the high dose level of 1.43 mg/L (190 ppm). These cosisted of: a
significant 33% reduction in group mean body weight, a significant 13%
reduction in feed consumption, signficantly reduced plasma urea and
histopathological evidence of adverse kidney effects. The histological
evidence of male rat nephrotoxicity is believed to be due to the
accumulation of alpha-2u-microglobin that is a mechcanism not relevant
ot human health. Therefore, the NOAEL for this study is the mid-dose of
0.25 mg/l (33.2 ppm). This study's results can be used to assist in the
development of Worker and General Population inhalation DNELs.
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