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EC number: 200-662-2 | CAS number: 67-64-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with generally accepted scientific standards, sufficient documentation of methodology and test results
Data source
Referenceopen allclose all
- Reference Type:
- other: data base
- Title:
- Acetone, CAS Number: 67-64-1, Assay: Micronucleus, Study ID: A71579
- Author:
- National Toxicology Program (NTP)
- Year:
- 1 993
- Bibliographic source:
- http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 991
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- NTP standard protocol
- GLP compliance:
- not specified
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- Acetone
- EC Number:
- 200-662-2
- EC Name:
- Acetone
- Cas Number:
- 67-64-1
- Molecular formula:
- C3H6O
- IUPAC Name:
- propan-2-one
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- B6C3F1
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: drinking water
- Duration of treatment / exposure:
- 13 wks
- Frequency of treatment:
- daily
- Post exposure period:
- 24 hrs
Doses / concentrations
- Remarks:
- Doses / Concentrations:
5,000, 10,000, 20,000 ppm
Basis:
nominal in water
- No. of animals per sex per dose:
- 10
- Control animals:
- yes, concurrent vehicle
- Positive control(s):
- none: because micronuclei were determined in test animals of a subchronic toxicity study
Examinations
- Tissues and cell types examined:
- Normochromatic erythrocytes in peripheral blood
- Details of tissue and slide preparation:
- CRITERIA FOR DOSE SELECTION: dosages corresponded to dose groups of subchronic toxicity study
TREATMENT AND SAMPLING TIMES: continuously in drinking water, sampling on last day of treatment
DETAILS OF SLIDE PREPARATION: ca. 10,000 - 15,000 normochromatic erythrocytes scored per test animal
METHOD OF ANALYSIS: acridine orange staining - Statistics:
- overall increase across all doses: positive trend test: p<=0.025
pairwise comparison of each dose group to the control group: significant increase of micronuclei p<=0.025
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
There was no indication of a clastogenic activity of acetone in normochromatic peripheral blood erythrocytes of B6C3F1 mice after subchronic oral exposure to acetone via drinking water (0.5-2 mg/kg bw/d). - Executive summary:
Groups of 10 B6C3F1 mice, that had continuously been exposed to 0, 0.5, 1 or 2 % acetone in drinking water for 13 weeks, were scored for induction of micronuclei in normochromatic erythrocytes in peripheral blood. Based on actual water consumption these concentrations correspond to dosages of 1,569, 3,023, and 5,481 mg/kg bw/d in male mice and dosages of 2,007, 4,156, and 5,945 mg/kg bw/d in female mice (values reported in NTP, 1991
). No indication of a clastogenic activity of acetone was found.
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