Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
additional toxicological information
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: data taken from existing studies on similar product
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
other: position paper
Title:
Unnamed
Year:
2006

Materials and methods

Type of study / information:
Position paper
Principles of method if other than guideline:
n/a

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
425-220-8
EC Name:
-
Cas Number:
5945-33-5
Molecular formula:
C39H34O8P2
IUPAC Name:
4-(2-{4-[(diphenoxyphosphoryl)oxy]phenyl}propan-2-yl)phenyl diphenyl phosphate; 4-{2-[4-({[4-(2-{4-[(diphenoxyphosphoryl)oxy]phenyl}propan-2-yl)phenoxy](phenoxy)phosphoryl}oxy)phenyl]propan-2-yl}phenyl diphenyl phosphate
Constituent 2
Reference substance name:
(1-methylethylidene)di-4,1-phenylene tetraphenyl diphosphate
IUPAC Name:
(1-methylethylidene)di-4,1-phenylene tetraphenyl diphosphate
Details on test material:
n/a

Results and discussion

Any other information on results incl. tables

See enclosed position paper on Neurotoxicty related to questions from CA RIVM, The Netherlands

Applicant's summary and conclusion

Conclusions:
Since the structure of BDP is very similar to that of RDP, one can “read across” with confi-dence that BDP does not have neurotoxic activity. Clearly, the chemical structure of BDP does not have the structural elements required to induce OPIDN via a neurotoxic metabolite. It therefore seems improper to conduct an animal study, just to confirm the lack of neurotoxic activity in a molecule that, because of its chemical structure, is obviously unable to inhibit NTE by 70% and cause OPIDN.
Executive summary:

Since the structure of BDP is very similar to that of RDP, one can “read across” with confi-dence that BDP does not have neurotoxic activity. Clearly, the chemical structure of BDP does not have the structural elements required to induce OPIDN via a neurotoxic metabolite. It therefore seems improper to conduct an animal study, just to confirm the lack of neurotoxic activity in a molecule that, because of its chemical structure, is obviously unable to inhibit NTE by 70% and cause OPIDN. If considered necessary, the above can be further clarified in a meeting.