Phosphoric acid, P,P'-[(1-methylethylidene)di-4,1-phenylene] P,P,P',P'-tetraphenyl ester

Additional toxicological data

Administrative data

Endpoint:

additional toxicological information

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: data taken from existing studies on similar product

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

other: position paper

Title:

Unnamed

Year:

2006

Materials and methods

Type of study / information:

Position paper

Principles of method if other than guideline:

n/a

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

425-220-8

EC Name:

-

Cas Number:

5945-33-5

Molecular formula:

C39H34O8P2

IUPAC Name:

4-(2-{4-[(diphenoxyphosphoryl)oxy]phenyl}propan-2-yl)phenyl diphenyl phosphate; 4-{2-[4-({[4-(2-{4-[(diphenoxyphosphoryl)oxy]phenyl}propan-2-yl)phenoxy](phenoxy)phosphoryl}oxy)phenyl]propan-2-yl}phenyl diphenyl phosphate

Constituent 2

Reference substance name:

(1-methylethylidene)di-4,1-phenylene tetraphenyl diphosphate

IUPAC Name:

(1-methylethylidene)di-4,1-phenylene tetraphenyl diphosphate

Details on test material:

n/a

Results and discussion

Any other information on results incl. tables

See enclosed position paper on Neurotoxicty related to questions from CA RIVM, The Netherlands

Applicant's summary and conclusion

Conclusions:

Since the structure of BDP is very similar to that of RDP, one can “read across” with confi-dence that BDP does not have neurotoxic activity. Clearly, the chemical structure of BDP does not have the structural elements required to induce OPIDN via a neurotoxic metabolite. It therefore seems improper to conduct an animal study, just to confirm the lack of neurotoxic activity in a molecule that, because of its chemical structure, is obviously unable to inhibit NTE by 70% and cause OPIDN.

Executive summary:

Since the structure of BDP is very similar to that of RDP, one can “read across” with confi-dence that BDP does not have neurotoxic activity. Clearly, the chemical structure of BDP does not have the structural elements required to induce OPIDN via a neurotoxic metabolite. It therefore seems improper to conduct an animal study, just to confirm the lack of neurotoxic activity in a molecule that, because of its chemical structure, is obviously unable to inhibit NTE by 70% and cause OPIDN. If considered necessary, the above can be further clarified in a meeting.