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EC number: 425-220-8
CAS number: 5945-33-5
See enclosed position paper on Neurotoxicty related to questions from CA
RIVM, The Netherlands
Since the structure of BDP is very similar to that of RDP, one can “read
across” with confi-dence that BDP does not have neurotoxic activity.
Clearly, the chemical structure of BDP does not have the structural
elements required to induce OPIDN via a neurotoxic metabolite. It
therefore seems improper to conduct an animal study, just to confirm the
lack of neurotoxic activity in a molecule that, because of its chemical
structure, is obviously unable to inhibit NTE by 70% and cause OPIDN. If
considered necessary, the above can be further clarified in a meeting.
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