Registration Dossier
Registration Dossier
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EC number: 425-220-8 | CAS number: 5945-33-5
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Read-across from analogue substance RDP, submitted on request of national CA regarding the endpoint neurotoxicity
Data source
Materials and methods
- Type of method:
- in vivo
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- RDP, analoque substance
Constituent 1
Administration / exposure
- Analytical verification of doses or concentrations:
- no
Results and discussion
- Details on results:
- 2000 mg/kg
NTE activity was minimal and no clinical signs of toxicity
were present.
5000 mg/kg
Delayed behavioral signs of neurotoxicity and
histomorphological changes in neural tissues were absent.
Based on the similarity of the structure of the substance
with the structures of structural analogues (Fyrolflex RDP
and TPP) and assuming that the double bond between oxygen
and phosphorus in TPP is stable, read across of
neurotoxicity data with Fyrolflex RDP is considered
acceptable. Therefore, there is no concern for workers with
regard to neurotoxicity.
Applicant's summary and conclusion
- Conclusions:
- No neurotoxicuty to be expected based on read-across from analoque substance
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