Glycollic acid

Solubility in organic solvents / fat solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

other: OECD 105 (EEC A.6)

GLP compliance:

yes

Medium:

other: hexane

Solubility:

< 0.043 g/kg solvent

Temp.:

25 °C

Medium:

methanol

Solubility:

other: > 1.02 g of Glycolic acid/g Methanol

Temp.:

22 °C

Remarks on result:

other: very soluble

Details on results:

Methanol: very soluble at 22°C

Conclusions:

Glycolic acid 70% solution was found to be very soluble in methanol. The solubility in hexane was reported to be <43 ppm (the limit of detection of the method).

Executive summary:

Solubility studies were run according to the OECD 105 (EEC A.6) method. Glycolic acid 70% solution was found to be very soluble in methanol; > 1.02 g of glycolic acid/g methanol. The solubility in hexane was reported to be < 43 ppm (the limit of detection of the method).

Reference 2

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

13 January 2021 - 18 August 2021

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

other: CIPAC MT 181

GLP compliance:

yes (incl. QA statement)

Key result

Medium:

acetone

Solubility:

> 250 g/L

Temp.:

20.2 °C

Key result

Medium:

isopropanol

Solubility:

>= 160 - <= 200 g/L

Temp.:

20.2 °C

Key result

Medium:

ethyl acetate

Solubility:

> 50 g/L

Temp.:

20.2 °C

Key result

Medium:

other: 1,2-dichloroethane

Solubility:

< 10 g/L

Temp.:

20.2 °C

Key result

Medium:

other: n-heptane

Solubility:

< 10 g/L

Temp.:

20.2 °C

Key result

Medium:

other: p-xylene

Solubility:

< 10 g/L

Temp.:

20.2 °C

Conclusions:

<10 g/L for n-heptane, p-xylene and 1,2-dichloroethane.

> 50 g/L ethyl acetate.

160 – 200 g/L propan-2-ol

>250 g/L acetone

Measurements were taken at room temperature (ca. 20.2 °C)

Description of key information

<10 g/L for n-heptane, p-xylene and 1,2-dichloroethane;

> 50 g/L ethyl acetate;

160 – 200 g/L propan-2-ol;

>250 g/L acetone.

Measurements were taken at room temperature (ca. 20.2 °C)

Additional information

Glycolic acid 70% solution was found to be very soluble in methanol: > 1.02 g of glycolic acid/g methanol. The solubility in hexane was reported to be < 43 ppm (the limit of detection of the method).