Lanthanum chloride, anhydrous

Developmental toxicity / teratogenicity

Administrative data

Endpoint:

developmental toxicity

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable, well documented publication which meets basic scientific principles. Non-standard treatment regimen.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

2006

Materials and methods

Principles of method if other than guideline:

Maternal rats were exposed to lanthanum from gestation day 0 through postnatal day 20. From postnatal day 20, pups were exposed to Lanthanum until postnatal day 150. Physical and neurobehavioural development of the pups was recorded, the DNA and protein/DNA concentrations were determined at postnatal day 30 and the Morris water mate test was conducted at postnatal day 150.

GLP compliance:

not specified

Limit test:

no

Test material

Test material information

Constituent 1

Details on test material:

- Name of test material (as cited in study report): Lanthanum Chloride
- Molecular formula (if other than submission substance): LaCl3
- Analytical purity: no data

Test animals

Species:

rat

Strain:

Wistar

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Animal Center of Beijing Medical University
- age: 7-9 weeks
- Housing: 5 in a polycarbonate cage

ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Route of administration:

other: oral: probably gavage

Vehicle:

not specified

Analytical verification of doses or concentrations:

no

Details on mating procedure:

- Female rats were mated with males of the same age and strain
- Proof of pregnancy: vaginal plug [day 0] of pregnancy
- No information about: length of cohabitation, success of copulation
- After successful mating each pregnant female was caged individually

Duration of treatment / exposure:

Dams: from gestation day 0 through postnatal day 20
Pups: from postnatal day 20 until they were killed (postnatal day 150)

Frequency of treatment:

probably daily during treatment period

Duration of test:

150 days

Doses / concentrations

Remarks:

Doses / Concentrations:
0, 0.1, 2 and 40 mg/kg/day
Basis:
nominal conc.

No. of animals per sex per dose:

15 maternal rats/dose
a total of 30 pups (equal numbers of males and females when possible) per dose

Control animals:

yes, concurrent no treatment

Results and discussion

Results (fetuses)

Effect levels (fetuses)

Dose descriptor:

NOAEL

Effect level:

40 mg/kg bw/day (nominal)

Basis for effect level:

other: teratogenicity

Fetal abnormalities

Abnormalities:

not specified

Overall developmental toxicity

Developmental effects observed:

not specified

Any other information on results incl. tables

- No differences in litter size between groups.

- No differences in pinna detachment and eye opening between groups.

- Body weights showed no significant differences among all groups on the 0 day. Compared to other groups, although no significant difference was observed, the body weight of the 2 mg/kg group was elevated on PND0 and PND30, with a significant difference on PND90. However, the weight gain of the 40 mg/kg group was decreased at all ages, with a significant difference at 5 months. This was not regarded a biologicallly significant effect.