Registration Dossier
Registration Dossier
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EC number: 208-765-4 | CAS number: 541-05-9
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
D3 hydrolyses rapidly. Although the intermediate hydrolysis product L3-diol has a log Kow > 3 (log Kow 3.2), it is anticipated to have a low potential for bioaccumulation. The final silanol hydrolysis product dimethylsilanediol has a low log Kowvalue (<3) and thus has low potential for bioaccumulation, and the requirement for testing is waived.
An experimental study conducted with the parent substance, D3, is disregarded due to significant methodological deficiences. The study had some significant deviations from guideline methods, and was not conducted according to GLP. Only one concentration was tested in the study, and the BCF was determined from samples sacrificed at one time point after 14 days of exposure. It is not possible to determine whether steady-state was reached. There was no depuration period. In addition, the pH dropped to below 6.5 in the study. The substance hydrolyses rapidly, and so the organisms were likely exposed to high concentrations of the hydrolysis product dimethylsilanediol as well as to the parent substance. Exposure to the intermediate hydrolysis products is also likely.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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