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EC number: 238-034-5 | CAS number: 14177-55-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
oral: LD50 (rat, female) > 300 - < 2000 mg/kg bw
Key value for chemical safety assessment
Additional information
Oral:
In a GLP-guideline study according to OECD guideline 423 and EU-Method B.1 tris (acute toxic class method) Molybdenum nickel tetraoxide was administered by gavage to a group of 6 female Sprague Dawley rats at the single dose of 2000 mg/kg bw (3 animals in a first and 3 animals in second step) and to a group of 6 female rats at the single dose of 300 mg/kg body weight (3 animals each in a third and fourth step) (Colas, 2010).
5 rats treated with 2000 mg/kg bw died within day 2 and day 4 post-exposure. Deaths were preceded by an absence or a decrease in spontaneous activity (5/5), in body temperature (1/5), in muscle tone (3/5), in Preyer’s reflex (1/5) and in righting reflex (1/5), dyspnea (1/5) and piloerection (4/5), which appeared only at 48 hours post-dose. Body weight was also decreased in the 5 animals on day 2 (4 -10% compared to control). Macroscopic examinations of the dead animals revealed a swelling of the stomach (5/5), a thickening of the corpus associated with white spots (2/5) or with a dark coloration (2/5), a thinning of the forestomach (5/5) and signs linked to rigor mortis.
The surviving animal dosed at 2000 mg/kg bw presented with decrease in spontaneous activity and in muscle tone and piloerection, which appeared only at 48 hours post-dose. The animal recovered a normal behaviour on day 5. A slight decrease in body weight (-4% compared to control) was noted on day 2; recovery was attained on day 7. The macroscopical examination of the animal did not reveal treatment related changes at the end of the study.
No mortality was observed in the 300 mg/kg bw dose group. In addition, no clinical signs were noted, body weight evolution remained normal throughout the study and no macroscopical changes were observed at the end of the study.
Thus, the LD50 of the test item Molybdenum nickel tetraoxide is higher than 300 mg/kg bw but lower than 2000 mg/kg bw by oral route in the rat. In accordance with the OECD guideline 423, the LD50 cut-off of the test item may be considered as 500 mg/kg bw by oral route in rats.
Justification for classification or non-classification
Based on the data on acute oral toxicity, Molybdenum nickel tetraoxide is classified as R22 "Harmful if swallowed" and as Acute Tox. 4 "Harmful if swallowed" according to the criteria of Directives 67/548/EEC (DSD) and 1272/2008/EC (CLP).
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