Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2004
Report Date:
2005

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Version / remarks:
and EU Method A.8 (Partition Coefficient)
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
2.79
Temp.:
26 °C
pH:
ca. 7

Any other information on results incl. tables

The HPLC method was performed using an analytical column Sperisorb ODS1 packed with a C18 solid phase containing long hydrocarbon chains chemically bound onto silica. The test item was eluted along the column by partitioning between the mobile solvent phase and the hydrocarbon stationary phase. The test item was retained in proportion to its hydrocarbon-water partition coefficient. Using reference items, a relationship between the retention time on reverse-phase column and the n-ocatnol/water partition coefficient was established. The mobil phase was methanol/water (65/35v/v).

Applicant's summary and conclusion