Acrylaldehyde

Additional toxicological data

Administrative data

Endpoint:

additional toxicological information

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1979-05-09 to 1979-06-11

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable, well documented study report which meets basic scientific principles

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1980

Report date:

1980

Materials and methods

Type of study / information:

inhalation toxicity, sensory (upper airway) irritation potential

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Measurement of mouse response to a sensory irritant, which is a reflex respiration rate decrease induced by trigeminal nerve stimutalion and phrenic nerve inhibition of respiration. The extent of respiration rate slowing is dose related. An RD50 (concentration of material required to produce a 50% respiration rate decrease) can be determined for sensory irritants by linear regression. Method according to Alarie 1973 and Kane, Barrow and Alarie (1979)

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Acrylaldehyde

EC Number:

203-453-4

EC Name:

Acrylaldehyde

Cas Number:

107-02-8

Molecular formula:

C3H4O

IUPAC Name:

acrylaldehyde

Details on test material:

- Name of test material (as cited in study report): Acrolein (CH2=CHCHO, Acrylaldehyde, Propenal, acrylic aldehyde)
no further data given
Acrolein was tested amoung other substances

Results and discussion

Any other information on results incl. tables

Maximum responses occured after ten minutes of exposure to the test material. The dose response curve was linear for concentrations below 2 ppm and the linear regression was calculated from these points. The RD50 for acrolein is 1.27 ppm (R=0.89, C.I. 1.07 to 1.52 ppm. The authors compared this results with results reported by Alarie. The RD50 values were quite similar (value reported by Alarie= 1.68 ppm). Haskell´s data agreed with Alarie´s data not only quantitatively, but also in the typ of response. Both groups found acrolein produces a uniform response over the ten minute exposure period.

Applicant's summary and conclusion

Executive summary:

In an Alarie test, which is an acute inhalation toxicity study designed to measure the mouse response to a sensory irritant, groups of 4 male Swiss mice were exposed head-only to acrolein (no information on a.i.). Exposure duration was 10 minutes and acrolein. Concentrations from 0.8.7 ppm were tested. The extent of dose related respiration rate slowing was determined and the RD50 (concentration of material required to produce a 50% respiration rate decrease) calculated.

Acrolein is a sensory irritant.

 

RD₅₀ Males =   1,27 ppm (R=0.89; 95% CI 1.07 - 1.52 ppm)

 

The dose response curve was linear for concentrations below 2 ppm. Maximum responses occures after 10 minutes of exposure to the test material.