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Diss Factsheets
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EC number: 271-231-4 | CAS number: 68526-83-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin
Topical application of isooctanol produced only signs of mild irritation in the rabbit following a 4 hour semi-occluded dermal patch exposure. Dermal observations were conducted 45 minutes, 24, 48 and 72 hours and 7 days after exposure. All animals survived the exposure. Well defined erythema was noted in 1 animal at the 45 minute point while the other animals had very slight erythema. Erythema increased after the 45 minute interval. Five animals were noted with well-defined erythema at the 24 and 48 hour intervals. At the 72 hour interval, all animals were noted with well-defined erythema. Erythema increased again at the Day 7 interval; two animals were noted with severe erythema and four animals were noted with well-defined erythema. The mean skin irritation scores between 24 and 72 hours were: erythema 1.89 and edema 1.22. Skin irritation had not resolved by the end of the study period (seven days).
In vitro evaluation of skin irritation potential by the Reconstructed Human Epidermis Test Method (OECD TG 439) suggests isooctanol is irritating to skin.
Eye
In this study, rabbits were administered isooctanol at a dose of 0.1 ml neat solution in the eye. Observations were made at 1, 4, 24, 48, and 72 h and 4 and 7 days post instillation. Eyes were scored for irritation in accordance with the Draize Eye Test. Signs of mild irritation were observed within 1 h post instillation, but resolved to unremarkable by Day 7. There were no signs of corneal damage in any of the test animals. Individual and mean eye irritation scores are reported in the endpoint study summary table. Four out of 6 animals had a mean cornea score of 1. These findings warrant the classification of isooctanol as an eye irritant Category 2 under EU GHS guidelines.
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: slightly irritating
Justification for classification or non-classification
According to the current UN criteria (http://www.unece.org/fileadmin/DAM/trans/doc/2011/dgac10c4/ST-SG-AC10-C4-2011-2e.pdf) adopted in June 2011 (http://www.unece.org/fileadmin/DAM/trans/doc/2011/dgac10c4/ST-SG-AC10-C4-42e.pdf) should be applied (see Example 2) while interpreting classification based on pre-OECD 405 test methods. Following these guidelines classification as eye irritation category 2 applies based on corneal observations. Classification for skin irritation category 2 is based on weight of evidence. In vivo testing indicates initially moderate skin irritation that does not resolve by seven days, but without corrosion. In vitro testing suggests isooctanol is irritating to skin. Together the weight of evidence for skin irritation suggests potential for a Category 2 skin irritant.
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