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EC number: 700-064-6 | CAS number: 2105830-60-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
- Endpoint:
- toxicity to soil macroorganisms except arthropods: short-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017-09-05 - 2018-02-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 207 (Earthworm, Acute Toxicity Tests)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Esterification product of castor oil and tetrahydromethyl-1,3-isobenzofuranedione
- EC Number:
- 700-064-6
- Cas Number:
- 2105830-60-0
- Molecular formula:
- Not applicable as this is a UVCB substance
- IUPAC Name:
- Esterification product of castor oil and tetrahydromethyl-1,3-isobenzofuranedione
1
Sampling and analysis
- Analytical monitoring:
- no
Test substrate
- Vehicle:
- yes
- Remarks:
- Acetone
- Details on preparation and application of test substrate:
- Based on the results of the range-finding test, a limit test was carried out. The nominal concentration was 1000 mg/kg. The blank control and the solvent control
were also canied out. 40 earthworms were exposed to each group, divided into four replicates of 10 earthworms each. The test duration was 14:days.
2520.1mg of the test substances was dissolved in 10mL acetone to give the solvent stock solution. The solvent stock solution was inverted several times to ensure adequate mixing and homogeneity. An aliquot solvent solution was separately added to a certain amount of silica sand and the solvent allowed to evaporate off prior to incorporation Into formulated artificial soil with deionised reverse osmosis water. These were mixed by a mixer to give the blank control, solvent control, 1000mg/kg respectively with a nominal moisture content of 40-60% by mass of the total water-holding capacity with the deionized water.
Test organisms
- Test organisms (species):
- Eisenia fetida
- Animal group:
- annelids
- Details on test organisms:
- The study was performed with earthworms (Eisenia fetida). This species was recommended in "Ministry of environmental protection of the people's Republic of
China, The Guidelines for the Testing of Chemicals - Effects on Biotic Systems, 2013, 207 Earthworm, Acute Toxicity Test" and .. OECD, Gutd~lines for the ·Testing of Chemicals, 1984, 207 Earthworm, Acute Toxicity Test".
The earthworms used in the limit test were purchased from Jiang Su province Jurong Stock Farm. (ID: EF-MKT-171027). All newly acquired earthworms were quarantined and observed for 14 days prior to use in the test. Earthworms were bred on a substrate consisting of 50% by volume peat and 50% by volume cow manure and kept under 20 ± 2°C for 7 days prior to testing. The test organisms were with clitellum and were transferred into artificial soil (without test substance) approximately 24 hours prior to the start of the test. At the start of the test, tH'e used adult earthworms, which were originated from the same ·population, were with clitellum and wet weight of 300 to 600mg.
Study design
- Study type:
- laboratory study
- Substrate type:
- artificial soil
- Limit test:
- yes
- Total exposure duration:
- 14 d
Test conditions
- Test temperature:
- 20.0 - 20.3 °C
- pH:
- 6.01 - 6.07
- Moisture:
- 29.51 - 31.64 (expressed as % dry weight)
- Nominal and measured concentrations:
- nominal 1000 mg/kg dry soil weight
- Reference substance (positive control):
- yes
Results and discussion
Effect concentrations
- Key result
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- The mortalities were 5.0% at the 7th day and 7.5% at the 14th day in the blank control group.
The mortalities were 5.0% at the th day and 5.0% at the 14th day in the solvent control group.
The mortalities were 5.0% at the 7th day and 10.0% at the 14th day in the 1000mglkg treatment group.
No adverse behavioural effects were observed at either 7 or 14 days exposure in any of the treatment groups - Results with reference substance (positive control):
- The LC50 of the toxic reference substance chloroacetamide was determined once a year.The most recent test with chloroacetamide was performed from 8th Nov. 2017 to 22nd Nov. 2017 (14 days test).
In this study, the reference substance was tested at five concentrations of 3.75, 7.50, 15, 30 and 60mglkg dry artificial soil weight. The mortalities in chloroacetamide treatment groups were shown to be between 0% to 100%. The 14-days LC50 for chloroacetamide was 21.60 mg/kg dry soil weight.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Expressed as nominal concentration, the median lethal concentration of MULTIESTER P97-463 on Eisenia fetida are as follows:
The 7 day LC50 value was higher than 1000 mglkg dry soil weight.
The 14 day LC50 value was higher than 1000 mglkg dry soil weight. - Executive summary:
Expressed as nominal concentration, the median lethal concentration of MULTIESTER P97-463 on Eisenia fetida are as follows:
The 7 day LC50 value was higher than 1000 mglkg dry soil weight.
The 14 day LC50 value was higher than 1000 mglkg dry soil weight.
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