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EC number: 222-598-4 | CAS number: 3547-33-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In a bacterial reverse mutation assay conducted with methods similar to OECD 471 guidelines, S. typhimurium strains TA98, TA100, TA1535 and TA1538 were treated with ethanol, 2-(octylthio) (96.9%) at concentrations of 0, 3, 10, 33 and 333 µg/plate in the presence and absence of rat liver S9 activation. No induced mutations were observed in the indicator strains in either the presence or absence of metabolic activation. At doses above 100 µg/plate, in the absence of activation, toxicity was moderate to extreme (U. S. EPA, 1995; National Industrial Chemicals Notification and Assessment Scheme, 1998). In another bacterial reverse mutation assay conducted similar to OECD 471 guidelines, 2-(octylthio)ethanol was not mutagenic to S. typhimurium strains TA 98, TA 100, TA1535 or TA1537 in the presence or absence of metabolic action at doses up to 100 µg/plate (Hazleton Laboratories, Inc., 1984).
In vitro mammalian cell gene mutation assays were conducted using L5178Y TK +/- or CHO cells. In the L5178Y TK +/- mouse lymphoma assay conducted with methods similar to OECD 476 guidelines results indicated that 2 -(octylthio)ethanol was non-mutagenic in both the presence and absence of metabolic activation (U.S., EPA, 1995; National Industrial Chemicals Notification and Assessment Scheme, 1998; Hazleton Laboratories America Inc., 1983). 2-(octylthiol)ethanol was also not mutagenic (endpoint not specified) in CHO cells in the presence or absence of metabolic activation (U.S. EPA, 1995).
In a chromosome aberration assay conducted with methods similar to OECD guideline 407, Chinese Hamster Ovary (CHO) cells were exposed for 10 hours to ethanol, 2-(octylthio) at concentrations ranging from 0.007-0.075 µL/mL in the absence of metabolic activation, and for 2 hours at concentrations ranging from 0.013-0.15 µL/mL in the presence of rat liver S9 activation. The test substance failed to induce structural chromosomal aberrations in either the presence or absence of metabolic activation, and was therefore considered non-mutagenic in the assay (National Industrial Chemicals Notification and Assessment Scheme, 1998). There were no increases in sister chromatid exchanges (SCEs) when CHO cells were treated with 2-(octythio)ethanol in the presence or absence or metabolic activation (Hazleton Laboratories America Inc., 1984).
2-(octylthio)ethanol did not induce an increase in unscheduled DNA synthesis in rat primary hepatocytes (U.S. EPA, 1995; National Industrial Chemicals Notification and Assessment Scheme, 1998).
Short description of key information:
2-(octylthiol)ethanol has been examined for genotoxicity in a range of recognized core in vitro assay types and has shown negative results.
Endpoint Conclusion:
Justification for classification or non-classification
2-(octylthiol)ethanol has been examined for genotoxicity in a range of recognized core in vitro assay types and has shown negative results. Therefore, 2-(octylthio)ethanol does not warrant classification as a mutagen under DSD or CLP.
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