Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 222-598-4 | CAS number: 3547-33-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: According to secondary source listed below, the study was conducted with methods similar to OECD guidelines.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Prevention, Pesticides and Toxic Substances Reregistration Eligibility Decision (RED) Hydroxyethyl Octyl Sulfide
- Author:
- U.S. EPA
- Year:
- 1 995
- Bibliographic source:
- EPA 738-R-96-001
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 410 (Repeated Dose Dermal Toxicity: 21/28-Day Study)
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Ethanol, 2-(octylthio)-
- IUPAC Name:
- Ethanol, 2-(octylthio)-
- Reference substance name:
- 2-(octylthio)ethanol
- EC Number:
- 222-598-4
- EC Name:
- 2-(octylthio)ethanol
- Cas Number:
- 3547-33-9
- Molecular formula:
- C10H22OS
- IUPAC Name:
- 2-(octylsulfanyl)ethan-1-ol
- Reference substance name:
- Hydroxyethyl octyl sulfide
- IUPAC Name:
- Hydroxyethyl octyl sulfide
- Details on test material:
- - Name of test material (as cited in study report): hydroxyethyl octyl sulfide
- Substance type: Active
- Physical state: Liquid
- Analytical purity: 100 %
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- corn oil
- Details on exposure:
- Repeated dermal applications of technical in corn oil, 6 hours/day, 7 days/week for 21 days; the vehicle control group received corn oil only on the same regimen
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 21 days
- Frequency of treatment:
- 6 hours/day, 7 days/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
50, 100 and 200 mg/kg
Basis:
nominal per unit body weight
- No. of animals per sex per dose:
- 5
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- No data
- Positive control:
- No
Examinations
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: Yes
- Cage side observations included: mortality and clinical signs of toxicity
DERMAL IRRITATION (if dermal study): Yes
BODY WEIGHT: Yes
FOOD CONSUMPTION: yes
HAEMATOLOGY: Yes
CLINICAL CHEMISTRY: Yes
OTHER: organ weights - Sacrifice and pathology:
- HISTOPATHOLOGY: Yes
- Other examinations:
- No data
- Statistics:
- No data
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Dermal irritation:
- effects observed, treatment-related
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- no effects observed
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- no effects observed
- Clinical biochemistry findings:
- no effects observed
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Gross pathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- no effects observed
- Histopathological findings: neoplastic:
- not specified
- Details on results:
- DERMAL IRRITATION: Treatment-related skin reactions were confined mainly to a proportion of animals receiving 100 or 200 mg/kg/day. Dermal reactions included: skin wrinkling in 1 male at 200 mg/kg/day; desquamation in 1 female at the vehicle control, 1 male and 1 female at 50 mg/kg/day, in 3 males and 2 females at 100 mg/kg/day, and in 5 males and 4 females at 200 mg/kg/day; and moderate to severe erythema usually in combination with moderate edema in 1 male and 1 female at the vehicle control and at 50 mg/kg/day, in 4 males and 0 females at 100 mg/kg/day, and in 4 males and 2 females at 200 mg/kg/day.
Effect levels
open allclose all
- Dose descriptor:
- NOEL
- Effect level:
- 50 mg/kg bw/day (nominal)
- Basis for effect level:
- other: Dermal irritation
- Dose descriptor:
- LOEL
- Effect level:
- 100 mg/kg bw/day (nominal)
- Basis for effect level:
- other: Dermal irritation
- Dose descriptor:
- NOEL
- Effect level:
- 200 mg/kg bw/day (nominal)
- Basis for effect level:
- other: Systemic toxicity
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Based on the results of the 21 day study, the NOEL for dermal irritation was 50 mg/kg/day and the LOEL was 100 mg/kg/day. For systemic toxicity, the NOEL was >200 mg/kg/day; a LOEL was not established.
- Executive summary:
In a 21-day dermal toxicity study, New Zealand white rabbits (5/sex/dose) were given repeated dermal applications of technical hydroxyethyl octyl sulfide (100%) in corn oil at doses of 50, 100 or 200 mg/kg, 6 hours/day, 7 days/week for 21 days; the vehicle control group (5/sex) received corn oil only on the same regimen. Treatment had no adverse effect on survival, clinical signs, mean body weights, body weight gain, food consumption, hematology, clinical chemistry, organ weights or gross histopathology. Treatment-related skin reactions were confined mainly to a proportion of animals receiving 100 or 200 mg/kg/day. Dermal reactions included: skin wrinkling in 1 male at 200 mg/kg/day; desquamation in 1 female at the vehicle control, 1 male and 1 female at 50 mg/kg/day, in 3 males and 2 females at 100 mg/kg/day, and in 5 males and 4 females at 200 mg/kg/day; and moderate to severe erythema usually in combination with moderate edema in 1 male and 1 female at the vehicle control and at 50 mg/kg/day, in 4 males and 0 females at 100 mg/kg/day and in 4 males and 2 females at 200 mg/kg/day. Based on these results, for dermal irritation the NOEL was 50 mg/kg/day and the LOEL was 100 mg/kg/day. For systemic toxicity the NOEL was > 200 mg/kg/day; a LOEL was not established.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.