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EC number: 603-373-3 | CAS number: 129909-90-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
No other available studies
Effect on fertility: via oral route
- Dose descriptor:
- NOAEL
- 73.2 mg/kg bw/day
Additional information
The parental systemic NOAEL for the 2-generation reproduction study in rats (Astroff, 1998) was 100 ppm (equivalent to 6.4/7.3 mg/kg/day [males/females]), based on decreased body weight and body weight gains seen at higher doses. There were no reproductive effects observed, thus the reproductive NOAEL was considered to be the maximum dose tested, 1000 ppm (equivalent to 73.2/84.0 mg/kg/day [males/females). The offspring NOAEL was considered to be 100 ppm (equivalent to 6.4/7.3 mg/kg/day [males/females]) based on decreased pup body weights and overall decreased body weights throughout treatment.
Short description of key information:
7.8.1 Toxicity to reproduction:
KS - 2gen.rat. Astroff, 1998. KL.1, NOAEL reproductive M: 73.2, F: 84 mg/kg/day; Offspring M: 6.4, F: 7.3 mg/kg/day
Effects on developmental toxicity
Description of key information
7.8.2 Developmental toxicity / teratogenicity:
KS - Terat.rat. Astroff & Young, 1999. KL.2, NOAEL Maternal and offspring 15 mg/kg/day
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 15 mg/kg bw/day
Additional information
In the developmental rat study (Astroff & Young, 1999) again effects on body weight were observed, with the maternal NOAEL considered to be 15 mg/kg/day. Developmental NOAEL was considered to be 15 mg/kg/day, based on multiple skeletal developmental retardations (including incomplete and unossified bones) observed at higher doses. When these findings are assessed in conjunction with the 2 generation study results, the skeletal retardations are thought not be a lasting adverse effect as foetal viability was not decreased in the 2-generation reproduction study. Furthermore these effects were only observed in the presence of maternal toxicity (reductions in body weight loss), with such effects not associated with any consistent syndrome of developmental effects in the rat (Chernoff, et al., 1988).
Reference:
Chernoff, N., Miller, D.B., Rosen, M.B. & Mattscheck, C.L. (1988). Developmental effects of maternal stress in the CD-1 mouse induced by restraint on single days during the period of major organogenesis. Toxicology., 51., pp 57 -65.
Justification for classification or non-classification
Developmental effects were only observed in the presence of maternal toxicity. No evidence of fertility effects were observed. Therefore amicarbazone has not been classified as teratogenic or causing an adverse effect on fertility.
Additional information
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