Registration Dossier
Registration Dossier
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EC number: 203-581-0 | CAS number: 108-42-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- other: Authoritative data base
- Title:
- ZVG No: 18790
- Author:
- IFA (GESTIS)
- Year:
- 2 011
- Bibliographic source:
- GESTIS - Substance Database (Information system on hazardous substances of the Berufsgenossenschaften)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-chloroaniline
- EC Number:
- 203-581-0
- EC Name:
- 3-chloroaniline
- Cas Number:
- 108-42-9
- Molecular formula:
- C6H6ClN
- IUPAC Name:
- 3-chloroaniline
- Details on test material:
- - Name of test material (as cited in study report):3-Chloroaniline
- Molecular formula:C6H6ClN
- Molecular weight:127.57
- Substance type:Organic
- Physical state:Liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- not specified
- Controls:
- not specified
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Reversibility:
- fully reversible
- Remarks on result:
- other: 3-Chloroaniline caused slight to moderate irritation to the conjunctiva but this was completely reversible; 3-Chloroaniline was therefore judged to be slightly to moderately irritating to the eyes.
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Reversibility:
- fully reversible
- Remarks on result:
- other: 3-Chloroaniline caused slight to moderate irritation to the cornea but this was completely reversible; 3-Chloroaniline was therefore judged to be slightly to moderately irritating to the eyes.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In a standardized test on rabbits' eyes (according to OECD guideline 405), 3-Chloroaniline caused slight to moderate irritation to the conjunctiva and cornea but this was completely reversible; 3-Chloroaniline was therefore judged to be slightly to moderately irritating to the eyes.
- Executive summary:
In a standardized test on rabbits' eyes (according to OECD guideline 405), 3-Chloroaniline caused slight to moderate irritation to the conjunctiva and cornea but this was completely reversible; 3-Chloroaniline was therefore judged to be slightly to moderately irritating to the eyes.
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