Registration Dossier
Registration Dossier
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Diss Factsheets
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EC number: 202-090-9 | CAS number: 91-68-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable and valid study, limited documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 957
- Report date:
- 1957
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Method: BASF-Test used before OECD Test Guidelines were in place
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-diethylaminophenol
- EC Number:
- 202-090-9
- EC Name:
- 3-diethylaminophenol
- Cas Number:
- 91-68-9
- Molecular formula:
- C10H15NO
- IUPAC Name:
- 3-(diethylamino)phenol
- Details on test material:
- - Name of test material (as cited in study report): Diäthyl-m-aminophenol
- Physical state: solid
- Analytical purity: 99 %
- Other: soluble in acetic acid, alcohol, lutrol, ethylenechloride, unsoluble in soda solution and vegetable oil
Constituent 1
Test animals
- Species:
- cat
- Strain:
- other: not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- - no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Traganth
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 1-5 %
- Amount of vehicle: 5-10 ml/kg bw - Doses:
- - 50, 200, 500 mg/kg bw
- No. of animals per sex per dose:
- - 50 mg: 2 animals
- 200 or 500 mg: 1 animal each
- sex not specified - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: up to 1 week
- Examinations performed: clinical signs, organ weights/ necropsy, body weight, haematology (methemoglobin)
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD0
- Effect level:
- 50 mg/kg bw
- Based on:
- test mat.
- Sex:
- not specified
- Dose descriptor:
- LD100
- Effect level:
- 200 mg/kg bw
- Based on:
- test mat.
- Mortality:
- A single oral administration of 200 or 500 mg/ kg bw was lethal within 1 day for both animals tested.
No mortality at 50 mg/ kg bw. - Clinical signs:
- other: 200 or 500 mg/ kg bw: Apathy, vomiting, excessive salivation, strong ataxia and tremor were noticed before excitus . In general symptoms of an anilin-like blood poisoning with formation of methemoglobin were observed. 50 mg: Salivation and vomiting aft
- Gross pathology:
- 200 mg/kg bw: collapsed lung, discolored liver
- Other findings:
- Methemoglobin formation was observed in all dose groups.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.