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EC number: 220-395-5 | CAS number: 2752-17-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1983-08-22 - 1983-09-12
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,2'-oxydi(ethylamine)
- EC Number:
- 220-395-5
- EC Name:
- 2,2'-oxydi(ethylamine)
- Cas Number:
- 2752-17-2
- Molecular formula:
- C4H12N2O
- IUPAC Name:
- 2-(2-aminoethoxy)ethan-1-amine
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 5601-22-1, Order #J-169
- Substance type: clear liquid
- Physical state: liquid
- Purity: responsibility of the sponsor
- Stability under test conditions: There was no apparent change in the physical state of the test article during administration.
- Other: Specific gravity - 0.955 gm/mL
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Blue Spruce Farms, Altamont, New York or Hilltop Lab Animals, Inc. Scottdale, Pennsylvania
- Weight at study initiation: 180 - 360 grams after fasting. The weight variation in animals or between groups did not exceed ± 20%
- Fasting period before study: yes
- Housing: Separate isolation by test system.
- Diet (e.g. ad libitum): Wayne Lab Blox, ad libitum, checked daily and added or replaced as needed. Feeders are designed to reduce soiling, bridging and scattering.
- Water (e.g. ad libitum): Availability - fresh tap water, fit for human consumption, ad libitum, using an automatic watering system supplied by Edstrom Industries, Inc. Waterford, Wisconsin.
- Acclimation period: five days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22°C ± 3°C
- Humidity (%): 30 to 70%
- Photoperiod (hrs dark / hrs light): 12 hours light, 12 hours dark
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- No data
- Doses:
- 400, 630, 1000, 1250 and 1600 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The rats were observed at approximately 1, 2, 4 and 24 hours after dosing and twice daily for 14 days for pharmacotoxic, CNS effects and mortality. On days 7 and 14, body weights were recorded.
- Necropsy of survivors performed: yes. The surviving rats were sacrificed by CO2 inhalation and a gross necrospy performed. - Statistics:
- According to the method of Litchfield and Wilcoxon (1949).
Results and discussion
- Preliminary study:
- Dose-range finder with 4 rats (2 males, 2 females) per concentration indicated:
1000 mg/kg: 3/4 died; 2000, 4000 and 8000 mg/kg: all rats died.
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 961 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 746 - <= 1 239
- Mortality:
- 400 mg/kg: 1 male died after 1 day
630 mg/kg: no mortality
1000 mg/kg: 1 male and 2 females died after 1 day, 1 female died after 2 days
1250 mg/kg: 2 males died after 1 day, 1 male after 2 days and 1 male after 11 days; 5 females died after 1 day
1600 mg/kg: 3 males died after 1 day and 1 male died after 5 days; 5 females died after 1 day - Clinical signs:
- other: Signs observed included decreased body tone and activity, poor grooming, piloerection, salivation, lacrimation, abnormal gait and stance, cyanosis, hypersensitivity, body drop, semi-prostration, diarrhea, dyspnea and prostration.
- Gross pathology:
- Necropsy of the animals dying on study revealed stomach and intestines fluid-filled and hemorrhagic. The lungs were congested and edematous. Discolored testes and spleen, pancreas, ulcers of the stomach, hydrothorax and hemorrhages of testicular connective tissue were also observed. Terminal necropsy revealed no visible lesions in any of the remaining animals.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Based upon the results of the acute oral toxicity study in rats, the calculated acute oral LD50 for male and female rats treated with the test substance was determined to be 961 mg/kg with confidence limits of 746 to 1239 mg/kg. Based on the results of this study and according to the CLP criteria, this substance should be classified as acute oral toxic category 4.
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