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EC number: 247-728-7 | CAS number: 26479-35-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study performed under GLP/OECD guideline without deficiency.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 436 (Acute Inhalation Toxicity: Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- Potassium carbamoylcarbamate
- EC Number:
- 247-728-7
- EC Name:
- Potassium carbamoylcarbamate
- Cas Number:
- 26479-35-6
- Molecular formula:
- C2H4N2O3.K
- IUPAC Name:
- potassium N-carbamoylcarbamate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): Potassium Allophonate
- Physical state:powder
- Analytical purity:83.8%
- Storage condition of test material: room temperature, in the dark
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: HsdHan:WIST
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:Male and female (nulliparous, non-pregnant) HsdHan:WIST strain rats from Harlan UK Ltd, Bicester.
- Age at study initiation:8 to 12 weeks old.
- Weight at study initiation:193 to 222 g (males) and 214 to 219 g (females).
- Fasting period before study: none
- Housing:
- Diet (e.g. ad libitum):SQC(E) Rat and Mouse Maintenance Diet No 1, from Special Diets Services Ltd, Witham, UK was freely available to the animals at all times.
- Water (e.g. ad libitum):Mains water was provided, ad libitum, via cage-mounted water bottles.
- Acclimation period: 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C):20 to 24 degrees C
- Humidity (%):45% to 65%
- Air changes (per hr):15 to 20
- Photoperiod (hrs dark / hrs light):12/12
IN-LIFE DATES: From 14 December 2011 to 28 December 2011
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- other: purified water
- Details on inhalation exposure:
- VEHICLE
- Composition of vehicle (if applicable):H2O
- Concentration of test material in vehicle (if applicable):25% w/v
- Justification of choice of vehicle: During the method development it was found that the target concentration of 5 mg/L specified in the protocol could not be achieved using the test article as supplied. The test article was therefore prepared as a solution in purified water at a concentration of 25% w/v.
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution:1-4μm
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.):3.46 μm
CLASS METHOD (if applicable)
- Rationale for the selection of the starting concentration: target concentration of 5 mg/L specified in the protocol could not be achieved - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- ca. 4 h
- Concentrations:
- 2.26mg/L.
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:Treated rats were observed at hourly intervals, commencing 30 minutes after the start of exposure, until the end of the working day. An additional observation was made when the animals were returned to their home cage (approximately 10 minutes after the end of the exposure). Animals were then observed once daily to the last day of the observation period. Individual records of clinical signs were
maintained for each treated rat.
- Necropsy of survivors performed: yes
- Other examinations performed: Clinical signs and body weight.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 2.26 mg/L air
- Based on:
- test mat.
- Mortality:
- negative
- Clinical signs:
- other: Signs of reaction to treatment were confined to vocalisation, red coloured staining on the head, unkempt appearance and wet fur. The signs developed from 10 minute after the end of the exposure period and lasted up to 3.5 hours after the end of the expos
- Body weight:
- All rats gained weight during the first and second weeks of the observation period.
- Gross pathology:
- No abnormalities were noted at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- The acute median lethal concentration of potassium allophonate was found to exceed 2.26 mg/L. It was not possible to classify the test material according to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), as it was not possible to obtain a respirable particle size at a concentration of greater than 5 mg/L.
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