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EC number: 927-344-2
CAS number: -
C9-14 aliphatics (2-25% aromatics) were not
dermal sensitizers using a Magnusson and Kligman Guinea-Pig Maximization
test (OECD TG 406). C9-14 aliphatics (2-25% aromatics) were not dermal
sensitizers in a Human Repeated Insult Patch Test (HRIPT).
Skin Response After Challenge
Animal – Exposure Group
This study examined the skin sensitization
potential of Dilutene M5. Groups of 10 male and 10 female guinea pigs
were induced with 0.1 % w/v of test substance in corn oil intradermally.
5 male and 5 female guinea pigs served as controls. The topical
induction was performed with 50% w/v of test substance in corn oil. A
topical challenge was then done with 25% w/v of test substance in corn
oil. Animals were then scored for dermal reactions. No reaction was seen
in any animal at any time during the experiment. The test substance is
not sensitizing to skin.
A skin sensitization study performed
according to Magnusson and Kligman Guinea-Pig Maximization test (OECD TG
406) found no indication of skin sensitization in guinea pigs for C9-14
aliphatics (2-25% aromatics). C9-14 aliphatics (2-25% aromatics) are not
skin sensitizers in humans. C9-14 aliphatics (2-25% aromatics) were
evaluated for its ability to induce skin sensitization in a 100+ person
Human Repeated Insult Patch Test (HRIPT).
There are no reports of respiratory
sensitization from C9-14 aliphatics (2-25% aromatics) in laboratory
animals or humans. However, a skin sensitization study utilizing C9-14
aliphatics (2-25% aromatics) found no indication of skin sensitization
in guinea pigs. Additional studies in humans also found no indication
of skin sensitization. With these observations, it is presumed that
C9-14 aliphatics (2-25% aromatics) will not be a respiratory sensitizing
These findings do not warrant the
classification of C9-14 aliphatics (2-25% aromatics) hydrocarbon
solvents as a skin or respiratory sensitizer under the new Regulation
(EC) 1272/2008 on classification, labeling and packaging of substances
and mixtures (CLP) or under the Directive 67/518/EEC for dangerous
substances and Directive 1999/45/EC for preparations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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