Registration Dossier
Registration Dossier
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EC number: 258-053-2 | CAS number: 52628-03-2
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
One key 48-hour Daphnia magna immobilization test; a second supporting study was also available.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 68 mg/L
Additional information
The purpose of this study was to evaluate the acute toxicity of the reaction product of 2-
hydroxyethyl methacrylate (HEMA) with polyphosphoric acid (PPA), hereafter refered to as
HEMA Phosphate, to the freshwater cladoceran, Daphnia magna, over a 48-hour exposure
period. The definitive test was conducted with 4 replicate vessels per test level, with 5
daphnids each, exposed to nominal concentrations of 0 (water control), 6.3, 13, 25, 50, and
100 mg HEMA Phosphate/L. The mean measured concentrations were <LLQ (water
control), 6.79, 14.8, 28.3, 55.5, and 105 mg HEMA Phosphate/L. Because the mean measure
concentrations were within 20% of the target concentrations, the acute toxicity values for
HEMA Phosphate with Daphnia magna were determined based on nominal concentrations.
The results were as follows:
• The 24-hour EC50 = 75 mg/L (95% confidence limits not calculable)
• The 48-hour EC50 = 68 mg/L ( 95% confidence limits 64 – 73 mg/L)
• The 48-hour NOEC = 50 mg/L
An earlier study in Daphnia magna demonstrated a 48 -hr EC50 to be >100 mg/L.
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