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EC number: 205-855-5 | CAS number: 156-43-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No data provided on guidelines compliance and no GLP compliance.
Data source
Reference
- Reference Type:
- publication
- Title:
- The Immunogenicity of Phenacetin and some of its Metabolites in Guinea Pigs
- Author:
- Frey JR, Geleick H, Geczy A,de Weck AL
- Year:
- 1 974
- Bibliographic source:
- Int. Arch. Allergy 46: 571-583 (1974)
- Report date:
- 1973
Materials and methods
- Principles of method if other than guideline:
- - Delayed type skin tests in vivo
-Specific stimulation of sensitized leukocytes in vitro - GLP compliance:
- no
- Type of study:
- Freund's complete adjuvant test
Test material
- Reference substance name:
- p-phenetidine
- EC Number:
- 205-855-5
- EC Name:
- p-phenetidine
- Cas Number:
- 156-43-4
- Molecular formula:
- C8H11NO
- IUPAC Name:
- 4-ethoxyaniline
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- other: White spotted Himalayan
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: closed colony (Bio, Fullinsdorf)
- Weight at study initiation: 400-500 g
- Diet (e.g. ad libitum): pellet diet with additional green vegetables ad libitum.
- Water (e.g. ad libitum): ad libitum
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal and epicutaneous
- Vehicle:
- other: FCA (Freund's complete adjuvant) (i.d.) and water (e.c.)
- Concentration / amount:
- Sensitizing procedures:
(a) 10 x 0.1 mg in water, i.d., on alternate days
(b) 5 x 1 mg in FCA, i.d., every 2 or 3 days
(c) 5 x 1 mg in water, i.d., every 2 or 3 days
(d) 10 x 10, 3, 1% in PEG
Challenge
- Concentration / amount:
- Sensitizing procedures:
(a) 10 x 0.1 mg in water, i.d., on alternate days
(b) 5 x 1 mg in FCA, i.d., every 2 or 3 days
(c) 5 x 1 mg in water, i.d., every 2 or 3 days
(d) 10 x 10, 3, 1% in PEG
- No. of animals per dose:
- 8 animals each group
- Details on study design:
- MAIN STUDY
INDUCTION EXPOSURE
- Exposure period: Induction of delayed hypersensitivity:
Epicutaneous tests: were performed 21-35 days after starting the sensitization course.The reactions were read after 24 h.
Intradermal tests: the tuberculine type reactions were read after 24 h.
- Test groups: phenacetin, N-acetyl-p-aminophenol, phenetidin HCl and 2-hydroxyphenetidin
- Control group: yes
- Site: clipped flank
- Frequency of applications: every 2 or 3 days
- Duration: until 21 days
- Concentrations:
Epicutaneous: 3, 1 and 0.3%
Intradermal: 1%
Results and discussion
Any other information on results incl. tables
Sensitization:
By injecting the four compounds intradermally at the rate of 5 times 1 mg in FCA, PT (phenetidine) and HPT induced contact and delayed hypersensitivity, whereas PA and NAPAP were inactive. In animals sensitized with HPT, epicutaneous cross-reactions with PT were elicited. In PT-sensitized animals, intradermal cross-reactions were elicited with PA and HPT and in HPT-sensitized animals with PT.
Similar results were obtained by injecting 10 times 0.1 mg of the four compounds in water on alternate days. The dose response curve established for PT showed that contact hypersensitivity was obtained with doses as low as 5 times 10 mcg..Doses of 1 mcg and less were inactive.
High degree of contact hypersensitivity to PT was also induced in all animals by epicutaneous application of PT in carbowaxat 10and 3°/o after 8-10 daily applications.
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information
- Conclusions:
- Sensitizing
- Executive summary:
Guinea pigs were sensitized by p-phenetidin and 2-hydroxy p-phenetidin, two minor metabolites of phenacetin, as demonstrated by delayed type skin tests in vivo and by specific stimulation of sensitized leukocytes in vitro, phenacetin itself and the major metabolite N-acetyl-p-aminophenol being inactive. On the other hand, p-phenetidin as well as phenacetin itself induce immunological tolerance and desensitization of already sensitized animals. In this system, however, exclusively the oral route appears to be effective for induction of immunological tolerance and desensitization, in contrast to the intravenous route which is effective in other haptenic systems.
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