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EC number: 931-210-9 | CAS number: 1266534-73-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
rat (oral, chronic): not carcinogenic, NOAEL = 60 mg/kg bw/d, highest dose tested (RA Zeolite cuboidal)
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 60 mg/kg bw/day
Justification for classification or non-classification
Based on the results obtained, Aluminium silicate and titanium oxide matrix doted with vanadium, nickel, and antimony does not fulfill the criteria to be classified for carcinogenicity according to DSD (67/548/EEC) or CLP (1272/2008/EC).
Additional information
No data for carcinogenicity are available for the target substance Aluminium silicate and titanium oxide matrix doted with vanadium, nickel, and antimony. Therefore, data from the analogue approach source substance Zeolite cuboidal were applied to cover the endpoint carcinogenicity for the target substance.
In an oral chronic toxicity study (Gloxhuber et al. 1979, RL2) male and female Wistar rats were fed at 0, 10, 100 and 1000 ppm of Zeolite, cuboidal, crystalline, synthetic, non-fibrous (Sasil, corresponding to about 0.6, 6.0 or 60 mg/kg bw/day) in the diet for 104 weeks (50 animals per dose group and sex).Analyses of the test substance concentrations in the diet were difficult due to the high concentrations of aluminum and silicon naturally occurring in rat diets. Body weights and mortality rates of the treated groups were not significantly different from the control group.No carcinogenic effects were observed. In animals dying during the test or killed due to their poor condition, the main causes were basophilic adenoma and adenocarcinoma of the pituitary gland, adenoma and fibroadenoma of the mammary glands, subcutaneous fibroma and some tumours of the genital tract. No significant incidence of a particular type of tumour or spontaneous mortality was evident in any group. No treatment-related findings were seen in any of the organs examined histologically and there was no indication of any treatment-related induction of neoplasms. Comparison of the separate sums of tumour changes observed in the 1000 ppm Zeolite (Sasil) and control groups showed no significant differences between the groups in the frequency of tumours.
Additional data for carcinogenicity after inhalation are available for the following source substances which serve as potential data sources for the analogue approach of Aluminium silicate and titanium oxide matrix doted with vanadium, nickel, and antimony:
- Source chemical 5 - Aluminium oxide (Gross et al. 1973)
- Source chemical 6 - Kaolin (Wagner 1987)
There was no evidence for a carcinogenic effect. However, as the inhalation route is not relevant for the target substance, the data are not considered relevant.
The respective references for the source substance data can be found in the data matrix of the justification for the analogue approach, which can be found either in the CSR or as attachment in Iuclid section 13.
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