Aluminum antimony nickel silicon titanium vanadium oxide

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

18 Nov - 03 Dec 2009

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP- Guideline srudy

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2010

Report date:

2010

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

Secretariat général du GIPC- DGCIS*SI - 12, rue Villiot, 75572 Paris cedex 12, France

Test type:

acute toxic class method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

silicon(4+) dialuminium(3+) antimony nickel vanadium pentaoxidandiide

EC Number:

931-210-9

Cas Number:

1266534-73-9

Molecular formula:

(M2/nO*Al2O3*ySiO2*wH2O)x*(Ti,Sb,Ni,V O2)z*(Al2O3)k*(Al2Si2O7)l n is the valency of the cation M, predominantly Na, and for Na is n=1; y can range from 2 to 222; w can range from 0 to 30; x can range from 0.2 to 0.7; z can range from 0.01 to 0.05; k can range from 0.03 to 0.39; l can range from 0.26 to 0.39

IUPAC Name:

silicon(4+) dialuminium(3+) antimony nickel vanadium pentaoxidandiide

Details on test material:

- Name of test material (as cited in study report): LOOP
- Chemical name: Aluminium silicate and titanium oxide matrix doted with vanadium, nickel, and antimony
- Analytical purity: 99%
- Lot/batch No.: 09303322/1
- Production date: 30 Jun 2009
- Expiration date of the lot/batch: 29 Jun 2011
- Storage condition of test material: room temperature

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Elevage JANVIER, 53940 Le Genest St Isle, France
- Age at study initiation: 8 weeks
- Weight at study initiation: 195-200 g
- Fasting period before study: 24 h before dosing, 4h after administration food was redistributed
- Housing: in groups of three in solid-bottomed clear polycarbonate cages
- Diet (e.g. ad libitum): M20, rat/mouse maintenance ad libitum
- Water (e.g. ad libitum): tap water from public distribution ad libitum
- Acclimation period: at least five days


ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-25
- Humidity (%): 30-70
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

olive oil

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 4 g in 10 mL
- Amount of vehicle (if gavage): 5mL/kg body weight

CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: assumed limit dose

Doses:

2000 mg/kg bw

No. of animals per sex per dose:

6 (3 animals in step 1 and step 2, respectively)

Control animals:

yes

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations were performed daily; animals were weighed just before substance administration and then on days 2, 7 and 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

current control study:
- study date: 04 Aug to 18 Aug 2009
- according to OECD 423
- 3 animals received the control item olive oil, administered by gavage (10 mL/kg bw)
- results: cinical examination: nothing to report, animals normal; Body weight evolution: normal during test, Necropsy: No treatment related changes.

Results and discussion

Effect levels

Sex:

female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Remarks on result:

other: According to the OECD Guideline 423, the LD50 cut-off of the test item may be considered higher than 5000 mg/kg bw.

Mortality:

No mortality occured during the observation period.

Clinical signs:

other: No clinical signs related to the administration of the test item were observed.

Gross pathology:

The macroscopical examination of the animals at the end of the study did not reveal treatment-related changes.