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Diss Factsheets
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EC number: 269-348-0 | CAS number: 68227-33-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Section 173.240 (a) (1) and Appendix A
- Principles of method if other than guideline:
- One group of six (3 male and 3 female) albino rabbits weighing between 2.0 and 3.0 kg each was employed in this study. All animals had their back clipped free of hair 24 hours prior to testing. All of the animals had their backs abraded prior to dosing.
The sample was dosed as supplied.
The following dosage level was administered: 1.0 mg/kg.
All rabbits were weighted and the correct amount of experimental material was applied to the back of each animal. These treated areas were covered with large gauze patches and an impervious material was wrapped snugly around the trunk of each animal. The dressings were removed after twenty-four hours and any excess material was removed and the approximate amount remaining was noted. The animals were observed for a 14 day period for signs of toxicity and for mortalities. Gross autopsies were performed onall animals which died during the 14 day observation period and also on all survivors of the 14 day observation period. - GLP compliance:
- no
- Test type:
- fixed dose procedure
Test material
- Reference substance name:
- 2,5,8,11-tetramethyldodec-6-yne-5,8-diol
- EC Number:
- 269-348-0
- EC Name:
- 2,5,8,11-tetramethyldodec-6-yne-5,8-diol
- Cas Number:
- 68227-33-8
- Molecular formula:
- C16H30O2
- IUPAC Name:
- 2,5,8,11-tetramethyldodec-6-yne-5,8-diol
- Reference substance name:
- 2,5,8,11-tetramethyl-6-dodecyne-5,8-diol
- IUPAC Name:
- 2,5,8,11-tetramethyl-6-dodecyne-5,8-diol
- Test material form:
- other: white waxy solid
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- other: albino
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 3 males and 3 females
Administration / exposure
- Type of coverage:
- other: gauze patches for 24 hours
- Vehicle:
- other: none
- Details on dermal exposure:
- 24 hours
- Duration of exposure:
- 24 hours
- Doses:
- 1.0 gr/kg bw
- No. of animals per sex per dose:
- 3 male
3 female - Control animals:
- no
Results and discussion
- Preliminary study:
- no prelimenary study
Effect levels
- Sex:
- male/female
- Dose descriptor:
- other: corrosion
- Effect level:
- > 1 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none
- Clinical signs:
- other: very slight edema and erythema
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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