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EC number: 269-348-0 | CAS number: 68227-33-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Section 1500.41 - Hazardous Substances and Articles, Administration and Enforcement Regulations, Federal Register, Vol. 38. No. 187, P. 27019, 27 September 1973
- Principles of method if other than guideline:
- The method empoyed in the testing, evaluation and the scoring of the results was similar to that described in Section 1500.41 - Hazardous Substances and Articles, Administration and Enforcement Regulations, Federal Register, Vol. 38. No. 187, P. 27019, 27 September 1973.
In carrying out the study the experimental sample was used as supplied. A group of six albino rabbits were clipped over a wide area. One side of the animals´ backs was abraded at one site with a lancet sufficiently deep to penetrate the stratum corneum but not enter the derma to produce bleedings. The skin of the other side was allowed to remain intact. A 0.5 gr. portion of material was applied to an abraded and an intact skin site on the same rabbit. Gauze patches were then placed over the treated areas vand an impervious material was wrapped snugly around the trunks of the animals to hold the patches in place.
The wrapping was removed at the end of the twenty-four hour period and the treated areas were examined. Readings were also made after seventy-two hours. The Draize Method of Scoring was employed. - GLP compliance:
- no
- Remarks:
- done before GLP was established
Test material
- Reference substance name:
- 2,5,8,11-tetramethyldodec-6-yne-5,8-diol
- EC Number:
- 269-348-0
- EC Name:
- 2,5,8,11-tetramethyldodec-6-yne-5,8-diol
- Cas Number:
- 68227-33-8
- Molecular formula:
- C16H30O2
- IUPAC Name:
- 2,5,8,11-tetramethyldodec-6-yne-5,8-diol
- Reference substance name:
- 2,5,8,11-tetramethyl-6-dodecyne-5,8-diol
- IUPAC Name:
- 2,5,8,11-tetramethyl-6-dodecyne-5,8-diol
- Test material form:
- other: waxy solid white
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- other: albino
Test system
- Type of coverage:
- other: gauze patches
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 g
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 72 h
- Number of animals:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Score:
- 5.17
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- >= 3 - <= 4
- Max. score:
- 4
- Reversibility:
- not specified
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- >= 2 - <= 3
- Max. score:
- 3
- Reversibility:
- not specified
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- >= 2 - <= 3
- Max. score:
- 3
- Reversibility:
- not specified
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- >= 2 - <= 3
- Max. score:
- 3
- Reversibility:
- not specified
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 3
- Reversibility:
- not specified
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- >= 2 - <= 3
- Max. score:
- 3
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 3
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 2
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- >= 2 - <= 3
- Max. score:
- 3
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- >= 2 - <= 3
- Max. score:
- 3
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- >= 2 - <= 3
- Max. score:
- 3
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- >= 2 - <= 3
- Max. score:
- 3
- Reversibility:
- not specified
Any other information on results incl. tables
Erythema and Eschar Formation Reading Rabbit Number Average
(Hours) 1 2 3 4 5 6
Intact skin 24 3 2 2 2 3 2 2.33
Intact skin 72 3 2 2 2 3 3 2.50
Abraded skin 24 3 2 2 2 3 2 2.33
Abraded skin 72 4 3 3 3 3 3 3.17
Subtotal: 10.33
Edema Formation Reading Rabbit Number Average
(Hours) 1 2 3 4 5 6
Intact skin 24 3 2 3 2 3 3 2.67
Intact skin 72 3 2 2 2 3 3 2.50
Abraded skin 24 3 2 3 2 2 2 2.33
Abraded skin 72 3 2 3 3 3 3 2.83
Subtotal: 10.33
Total: 20.66
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- Based on the accompanying table, the subject material would be classified as a primary irritant to albino rabbits within the definition of the act-reference: Section 1500.3 (c) (4) and requires cautionary labeling with respect to that section.
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