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Ecotoxicological information
Short-term toxicity to aquatic invertebrates
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Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- 1.11
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 5.18 mg/L
- Validity criteria fulfilled:
- not specified
- Conclusions:
- LC50 of daphnia is 5.180 mg/L of terpinene-4-ol.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- 1.11
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1.706 mg/L
- Validity criteria fulfilled:
- not specified
- Conclusions:
- LC50 of daphnia is 1.706 mg/L for acetate linalyle.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- 1.11
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 13.38 mg/L
- Validity criteria fulfilled:
- not specified
- Conclusions:
- LC50 of daphnia is 13.380 mg/L for borneol.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- 1.11
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 9.019 mg/L
- Validity criteria fulfilled:
- not specified
- Conclusions:
- LC5 of daphnia is 9.019 mg/L for camphor.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- 1.11
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 7.669 mg/L
- Validity criteria fulfilled:
- not specified
- Conclusions:
- LC50 of daphnia is 7.669 mg/L for cineol.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- 1.11
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.216 mg/L
- Validity criteria fulfilled:
- not specified
- Conclusions:
- LC50 of daphnia is 0.216 mg/L for E-beta ocimene.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- 1.11
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.238 mg/L
- Validity criteria fulfilled:
- not specified
- Conclusions:
- LC50 of daphnia is 0.238 mg/L for limonene.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Justification for type of information:
- Data come from an online compilation using secondary data sources , from HPV chemical data base (OECD SIDS) and UNEP publications.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- GLP
- GLP compliance:
- yes
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 59 mg/L
- Details on results:
- All concentrations listed refer to average measured concentrations. The 48-h EC50 was calculated to be 59 mg/l (53-65 mg/l, 95% CL); the observed EC100 was above the maximum average concentration of 75 mg/l, the EC0 and NOEC were 25 mg/l.
Immobilisation after 24 h was found in 17/20 daphnids (4, 4, 4 and 5 per group of 5) and after 48 h in 19/20 daphnids; no immobilisation was noted at lower test concentrations nor in the controls.
Measured concentrations ranged between 85 and 99% of nominal at time 0 and between 51 and 72% at time 48 h, the average of both being between 70 and 81%. - Validity criteria fulfilled:
- not specified
- Conclusions:
- LC50 of daphnia is 59 mg/L for linalol.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- 1.11
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.216 mg/L
- Validity criteria fulfilled:
- not specified
- Conclusions:
- LC50 of daphnia is 0.216 mg/L for myrcene.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- 1.11
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.252 mg/L
- Validity criteria fulfilled:
- not specified
- Conclusions:
- LC50 of daphnia is 0,252 mg/L for (z)-beta ocimene.
Referenceopen allclose all
Description of key information
Based on a weight of evidence approach, the acute toxicity of lavandin oil light fraction to aquatic invertebrates (daphnia) can be estimated using adequate toxicity date of major constituents, greater than 1% in the mixture. Ten constituents represent about 92% of the UVCB substance.These data are summarized in the table below :
| Constituent name | CAS number | LC50 daphnia 48h (mg/L) | Source | |
| Limonene (2%) | 5989-27-5 | 0.238 | ECOSAR V1.11 | |
| Cineol (1,5%) | 470-82-6 | 7.669 | ECOSAR V1.11 | |
| Z-beta ocimene (10%) | 3338-55-4 | 0.252 | ECOSAR V1.11 | |
| Linalol (65%) | 78-70-6 | 59 | OECD SIDS | |
| Camphor (13%) | 76-22-2 | 9.019 | ECOSAR V1.11 | |
| Terpinene-4-ol (3%) | 562-74-3 | 5.180 | ECOSAR V1.11 | |
| Linalyl acetate (1%) | 115-95-7 | 1.706 | ECOSAR V1.11 | |
| Borneol (1%) | 507-70-0 | 13.38 | ECOSAR V1.11 | |
| Myrcene (1%) | 123-35-3 | 0.216 | ECOSAR V1.11 | |
| E-beta ocimene (1,5%) | 3779-61-1 | 0.216 | ECOSAR V1.11 | |
Using additivity formula mentionned in CLP regulation 1272/2008 in section 4.1.3.5.2., the LC50 daphnia for the lavandin oil light fraction is estimated at 2.94 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 2.94 mg/L
Additional information
With a LC50 daphnia value of 2.94 mg/l and some constituents (linalol and camphor with log Kow <4 representing more than 78% of the UVCB substance), the substance is classified H411 according to the table 4.1.0 b) ii) of CLP regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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