Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 309-916-8 | CAS number: 101357-19-1
Endpoint summary
Administrative data
Description of key information
Hydrolysis
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical Benzenamine, N,N-dimethyl-, oxidized, molybdatetungstatephosphates can be expected to be range from > 29 to < 146 days, respectively. Thus, based on this, test chemical Benzenamine, N,N-dimethyl-, oxidized, molybdatetungstatephosphates is considered to be not hydrolysable in water.
Biodegradation in water
Estimation Programs Interface Suite was run to predict the biodegradation potential of the test compound Benzenamine, N,N-dimethyl-, oxidized, molybdatetungstatephosphates (CAS no. 101357 -19 -1) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical Benzenamine, N,N-dimethyl-, oxidized, molybdatetungstatephosphates is expected to be not readily biodegradable.
Adsorption
The adsorption coefficient Koc in soil and in sewage sludge of test chemical Benzenamine, N,N-dimethyl-, oxidized, molybdatetungstatephosphates (CAS no. 101357 -19 -1) was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 121 for testing of Chemicals (Experimental study report, 2018). The solutions of the test substance and reference substances were prepared in appropriate solvents. A test item solution was prepared by accurately weighing 4 mg of test item and diluted with Acetonitrile up to 10 ml. Thus, the test solution concentration was 400 mg/l. The pH of test substance was 6.2. Each of the reference substance and test substance were analysed by HPLC at 210 nm. After equilibration of the HPLC system, Urea was injected first, the reference substances were injected in duplicate, followed by the test chemical solution in duplicate. Reference substances were injected again after test sample, no change in retention time of reference substances was observed. Retention time tR were measured, averaged and the decimal logarithms of the capacity factors k were calculated. The graph was plotted between log Koc versus log k(Annex - 2).The linear regression parameter of the relationship log Koc vs log k were also calculated from the data obtained with calibration samples and therewith, log Koc of the test substance was determined from its measured capacity factor. The reference substances were chosen according to estimated Koc range of the test substance and generalized calibration graph was prepared. The reference substances were Acetanilide, 4-chloroaniline, 4-methylaniline(p-Tolouidine), N-methylaniline, p-toluamide, Aniline, 2,5-Dichloroaniline, 4-nitrophenol, 2 - nitrophenol, 2 -nitrobenzamide, 3-nitrobenzamide, Nitrobenzene, 4-Nitrobenzamide, 1-naphtol, Direct Red 81, Benzoic acid methylester, Carbendazim, Benzoic acid phenylester, Xylene, Ethylbenzene, Toluene, Naphthalene, 1,2,3 -trichlorobenzene, Pentachlorophenol, 3,5-dinitrobenzamide, Benzamide, phenanthrene having Koc value ranging from 1.25 to 4.09. The Log Koc value of test chemical Benzenamine, N,N-dimethyl-, oxidized, molybdatetungstatephosphates was determined to be 1.256± 0.007 at 25°C. This log Koc value indicates that the substance Benzenamine, N,N-dimethyl-, oxidized, molybdatetungstatephosphates has a negligible sorption to soil and sediment and therefore have rapid migration potential to ground water.
Additional information
Hydrolysis
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical Benzenamine, N,N-dimethyl-, oxidized, molybdatetungstatephosphates (CAS no. 101357 -19 -1). The studies are as mentioned below:
The half-life value of test chemical was determinedat a pH range 5-9 and at a temperature of 55°C, respectively. The estimated half-life value of test chemical was determined to be ranges from 29 to 146 days, respectively. Based on the half-life values, it is concluded that the test substance is not hydrolysable.
In an another study, the half-life of the test chemical was determined using an estimated pseudo-first order hydrolysis rate constant of 0.00000021/sec.The half-life of test substance was determined to be 38 days at pH 7 and a temperature of 25°C, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical Benzenamine, N,N-dimethyl-, oxidized, molybdatetungstatephosphates can be expected to be range from > 29 to < 146 days, respectively. Thus, based on this, test chemical Benzenamine, N,N-dimethyl-, oxidized, molybdatetungstatephosphates is considered to be not hydrolysable in water.
Biodegradation in water
Predicted data for the target compound Benzenamine, N,N-dimethyl-, oxidized, molybdatetungstatephosphates (CAS no. 101357 -19 -1) and various supporting weight of evidence studies for its structurally and functionally similar read across substance were reviewed for the biodegradation end point which are summarized as below:
In a prediction done using the Estimation Programs Interface Suite was run to predict the biodegradation potential of the test compound Benzenamine, N,N-dimethyl-, oxidized, molybdatetungstatephosphates (CAS no. 101357 -19 -1) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical Benzenamine, N,N-dimethyl-, oxidized, molybdatetungstatephosphates is expected to be not readily biodegradable.
In a supporting weight of evidence study from authoritative database (2018),biodegradation experiment was conducted for 28 days for evaluating the percentage biodegradability of test substance. The study was performed according to OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I). Activated sludge was used as a test inoculums for the study. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to be 1 and 0% by BOD, TOC removal and HPLC parameter in 28 days. Thus, based on percentage degradation, test chemical is considered to be not readily biodegradable in nature.
For the test chemical,Biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test substance (authoritative database, 2018). The study was performed according to OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I) under aerobic conditions. Activated sludge was used as a test inoculums for the study. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to be 0 and 1% by BOD and TOC removal parameter in 28 days. Thus, based on percentage degradation, test chemical is considered to be not readily biodegradable in nature.
Another biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test substance (secondary source, 2017). The study was performed according to OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I) under aerobic conditions. Activated sludge was used as a test inoculums for the study. Initial test substance conc. used in the study was 100 mg/l. The percentage degradation of test substance was determined to be 0% by O2 consumption parameter in 28 days. Thus, based on percentage degradation, test chemical is considered to be not readily biodegradable in nature.
On the basis of above results for target chemical Benzenamine, N,N-dimethyl-, oxidized, molybdatetungstatephosphates (from modelling database, 2018), it can be concluded that the test substance Benzenamine, N,N-dimethyl-, oxidized, molybdatetungstatephosphates can be expected to be not readily biodegradable in nature.
Adsorption
The adsorption coefficient Koc in soil and in sewage sludge of test chemical Benzenamine, N,N-dimethyl-, oxidized, molybdatetungstatephosphates (CAS no. 101357 -19 -1) was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 121 for testing of Chemicals (Experimental study report, 2018). The solutions of the test substance and reference substances were prepared in appropriate solvents. A test item solution was prepared by accurately weighing 4 mg of test item and diluted with Acetonitrile up to 10 ml. Thus, the test solution concentration was 400 mg/l. The pH of test substance was 6.2. Each of the reference substance and test substance were analysed by HPLC at 210 nm. After equilibration of the HPLC system, Urea was injected first, the reference substances were injected in duplicate, followed by the test chemical solution in duplicate. Reference substances were injected again after test sample, no change in retention time of reference substances was observed. Retention time tR were measured, averaged and the decimal logarithms of the capacity factors k were calculated. The graph was plotted between log Koc versus log k(Annex - 2).The linear regression parameter of the relationship log Koc vs log k were also calculated from the data obtained with calibration samples and therewith, log Koc of the test substance was determined from its measured capacity factor. The reference substances were chosen according to estimated Koc range of the test substance and generalized calibration graph was prepared. The reference substances were Acetanilide, 4-chloroaniline, 4-methylaniline(p-Tolouidine), N-methylaniline, p-toluamide, Aniline, 2,5-Dichloroaniline, 4-nitrophenol, 2 - nitrophenol, 2 -nitrobenzamide, 3-nitrobenzamide, Nitrobenzene, 4-Nitrobenzamide, 1-naphtol, Direct Red 81, Benzoic acid methylester, Carbendazim, Benzoic acid phenylester, Xylene, Ethylbenzene, Toluene, Naphthalene, 1,2,3 -trichlorobenzene, Pentachlorophenol, 3,5-dinitrobenzamide, Benzamide, phenanthrene having Koc value ranging from 1.25 to 4.09. The Log Koc value of test chemical Benzenamine, N,N-dimethyl-, oxidized, molybdatetungstatephosphates was determined to be 1.256± 0.007 at 25°C. This log Koc value indicates that the substance Benzenamine, N,N-dimethyl-, oxidized, molybdatetungstatephosphates has a negligible sorption to soil and sediment and therefore have rapid migration potential to ground water.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
