Registration Dossier
Registration Dossier
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EC number: 284-325-5 | CAS number: 84852-15-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
One out of three Guinea Pig Maximization tests are rated Klimisch 1 (Huels #0690). In this test all induction sites of test and control animals treated with FCA showed intense erythema, swelling and necrosis. Treatment with 1% test substance in corn oil induced distinct erythema and swelling. Corn oil showed slight erythema and swelling. After patch test all induction sites with FCA showed bloody inflammations. 24 hours after patch removal distinct erythema and swelling occurred on the application sites and at the shoulder area (test animals). All injection sites showed incrustations (test and control animals).
Distinct local effects are caused by the irritating/corrosive properties of the substance. Nonylphenol is not considered a dermal sensitizer based one reliable OECD 406 study and two supporting GPMT tests.
Migrated from Short description of key information:
Nonylphenol shows no sensitizing potential in three guinea pig maximization tests according OECD 406.
Justification for classification or non-classification
Iso-nonylphenol does not show sensitizing potential in an OECD 406 guideline study. No classification is necessary.
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