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EC number: 284-325-5 | CAS number: 84852-15-3
Endpoint summary
Administrative data
Description of key information
For fish species, Watanabe et al (2017) is the Key Study and the key value is a NOEC for fertilised eggs (fertility) in the Japanese medaka (Oryzias latipes) F0 and F1 generations of 0.000127 mg/L or 1.27µg/L. For invertebrate species, Comber et al (1993) provided a 21-day NOEC (reproduction) of 0.024 mg/L nonylphenol for the preferred species, Daphnia magna. For algal species, the Scholz (1989) study was selected as a key study because it provides both an EC50 (1.3 mg nonylphenol/L) and EC10 (0.5 mg nonylphenol/L) concentration for growth inhibition for a common algal test speciesDesmodesmus subspicatus. Ward and Boeri (1990) was also selected as a key study because it provides EC50 toxicity information for the preferred algal test organism Pseudokirchneriella subcapitata and of the marine algae Skeletonema costatum, although a non-standard test duration (96 hours) determining 96 h EC50s of 0.41 mg/L and 0.027 mg nonylphenol/L, respectively.
A number of additional studies have been added to the long term toxicity sections for fish, invertebrates and algae. Two chronic toxicity tests on invertebrate species remain ongoing at the time of the update in December 2019; Kimmel (2020) on Potamopyrgus antipodarum and Huntsmans (2020) on Crassostrea gigas. The decision has been taken not to update the PNEC until all of the new data is available at end 2020/early 2021, as the additional studies will require a further update of the PNEC at this time.
Additional information
The review of nonylphenol exposure to aquatic organisms resulted in reliable toxicity tests covering freshwater and saltwater species of fish, invertebrates, algae and an amphibian. Toxicity test results indicated fish were more sensitive to the toxic effects of nonylphenol than invertebrates, algae or amphibians for acute, short-term exposures. Freshwater fish were more sensitive also when considering short-term, withthe lowest LC50 for survival for fish and invertebrates of 0.01 and 0.08 mg nonylphenol/L, respectively. Toxicity data for long-term exposure to nonylphenol indicated the lowest NOEC value of 0.00127 mg nonylphenol/L for fertilised eggs in adult and first-generation fish was similar to the lowest NOEC of 0.001 mg nonylphenol/L for invertebrate growth inhibition.
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