Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 264-092-6 | CAS number: 63310-16-7
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
96 h LL50 = > 1000 mg/L; 96 h NOELR = 1000 mg/L, Oncorhynchus mykiss, OECD 203, EU Method C.1, Wetton (2002a)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1 000 mg/L
Additional information
The acute toxicity of the test material to fish was investigated in Oncorhynchus mykiss (rainbow trout) in accordance with standardised guidelines OECD 203 and EU Method C.1. Following a range finding study, 30 fish were exposed to a Water Accommodated Fraction (WAF) of the test material at a single nominal loading rate of 1000 mg/L for a period of 96 hours under semi-static conditions. The number of mortalities and sub-lethal effects of exposure in each test and control vessel were determined 3, 6, 24, 48, 72 and 96 hours after the start of the exposure. Under the conditions of the study, there were no mortalities nor sub-lethal effects at a 1000 mg/L loading rate WAF for a period of 96 hours. The LL50 was therefore determined to be in excess of 1000 mg/L loading rate WAF and the No Observed Effect Loading rate determined to be 1000 mg/L loading rate WAF. Samples of the control and 1000 mg/L loading rate WAF were taken at 0 (fresh media) and 24 hours (old media) for Total Organic Carbon (TOC) analysis. The results indicated that a soluble component of the test material was present in the test preparations. Since the test material was a mixture of components, and given that toxicity could therefore not be attributed to a single component or a mixture of components but to the test material as a whole, the results were based on nominal loading rates only.
The study was performed in line with GLP and accepted standardised guidelines with a high standard of reporting. The study was assigned a reliability score of 1 and considered suitable for assessment as an accurate reflection of the test material.
The available data are considered to be complete and the results determined, 96 h LL50 value of greater than 1000 mg/L loading rate WAF and 96 h NOELR value of 1000 mg/L loading rate WAF, were taken forward for risk assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
