Registration Dossier
Registration Dossier
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EC number: 258-981-8 | CAS number: 54112-23-1
Endpoint summary
Administrative data
Description of key information
According to Regulation (EC) No. 1907/2006, Annex VIII, 8.6.1, column 2, this short-term toxicity study (28 days) does not need to be conducted if a reliable sub-chronic (90 days) study is available.
A reliable sub-chronic (90 days) has been performed with the test substance, applying 0 (control), 100, 300 and 1000 mg/kg bw/d per oralis to rats. In lack of any adverse treatment-related effects observed during the treatment period and the recovery period the No Observed Effect Level (NOEL) in this study was set to 1000 mg/kg bw/d (highest dose tested in this study).
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Based on the results of an oral subchronic repeated dose toxicity study, not revealing any effects when dosed up to 1000 mg/kg bw/d (p.o.), the substance is not subject to classification and labelling for STOT repeat exposure according to CLP (Regulation EC No. 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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