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EC number: 229-765-0 | CAS number: 6713-03-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 04 August 2017 to 11 October 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- See 'Principales of method if other than guideline'
- Principles of method if other than guideline:
- The temperature of the test room varied by more than 1°C. This is not expected to affect the results of the test as the temperature remained within 18-22°C and no significant mortality was observed in the controls. The D. magna used in the range-finding test were up to 48h old at test initiation. This was due to poor yield from the ephippia at 72h. This is not expected to affect the results of the test as the range-finding test is only used to determine the concentrations which the definitive test will use. The D. magna used in the definitive test were hatched from ephippia, rather than sourced from live adults. This is not expected to affect the results of the test.
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: Dilution series - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Source: hatched from ephippia sourced from MicroBio Tests - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Remarks on exposure duration:
- Observations were recorded at 24 hours and 48 hours of exposure to test substance
- Hardness:
- Not specified
- Test temperature:
- 20 +/- 2°C
- pH:
- 6 - 9
- Dissolved oxygen:
- 8.69-8.97 mg/l
- Nominal and measured concentrations:
- Nominal concentrations: 1, 10, 100, and 1000 mg/L.
- Details on test conditions:
- TEST SYSTEM
- Test vessel: borosilicate glass crystallising dishes
- Type: closed
- Material, size, headspace, fill volume: 100 ml
- Aeration: No aeration during the 48 hour study
- Type of flow-through: static
- No. of organisms per vessel: 10 animals per vessel
- No. of vessels per concentration (replicates): 2 vessels per concentration
- No. of vessels per control (replicates): 2 vessels per control
- No. of vessels per vehicle control (replicates): 2 vessels per control
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: ISO reconstituted water (as specified in OECD 202)
- Intervals of water quality measurement: Carried out at each concentration at 0h and 48h
EFFECT PARAMETERS MEASURED: Immobilisation
OTHER TEST CONDITIONS
- Photoperiod: 16h light / 8h dark
RANGE-FINDING STUDY
- Test concentrations: 1000, 100, 10 and 1 mg/l
- Results used to determine the conditions for the definitive study: yes - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1 920 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 2 830 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 320 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Behavioural abnormalities: None reported
- Observations on body length and weight: None reported
- Mortality of control: < 10% control mortality observed
- Abnormal responses: None reported - Results with reference substance (positive control):
- - Results with reference substance valid?
Yes
- Relevant effect levels: Yes
- Limit test: No
- Dose-response test: Yes
- ECx: 24h EC50 = 1.16 mg/L - Reported statistics and error estimates:
- Results for both range-finding and definitive tests were calculated by Linear Interpolation within the CETIS suite of statistical analysis.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 48-hour EC50 was 1,920 mg/L and the 48-hour NOEC 320 mg/L. The substance did not meet the criteria for classification as toxic to the aquatic environment according to Regulation (EC) N° 1272/2008.
- Executive summary:
The short-term toxicity of 1-[(2-hydroxyethyl)thio]propan-2-ol to aquatic invertebrates was determined during a GLP-compliant study performed according to the OECD Testing Guideline 202.
The species was Daphnia magna.
A range-finding test was performed to determine the concentrations to be used during the definitive test. As a result of this range-finding test, concentrations of 100, 320, 1,000, 3,200 and 10,000 mg/L were used during the definitive test.
The 48-hour EC50 was 1,920 mg/L and the 48-hour NOEC 320 mg/L. The substance did not meet the criteria for classification as toxic to the aquatic environment according to Regulation (EC) N° 1272/2008.
Reference
Description of key information
The short-term toxicity of 1-[(2-hydroxyethyl)thio]propan-2-ol to aquatic invertebrates was determined during a GLP-compliant study performed according to the OECD Testing Guideline 202.
The species was Daphnia magna.
A range-finding test was performed to determine the concentrations to be used during the definitive test. As a result of this range-finding test, concentrations of 100, 320, 1,000, 3,200 and 10,000 mg/L were used during the definitive test.
The 48-hour EC50 was 1,920 mg/L and the 48-hour NOEC 320 mg/L. The substance did not meet the criteria for classification as toxic to the aquatic environment according to Regulation (EC) N° 1272/2008.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 1 920 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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