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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 229-765-0 | CAS number: 6713-03-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_classification-and-labelling-and-pbt-assessment.png)
PBT assessment
Administrative data
PBT assessment: overall result
- Name:
- 1-[(2-hydroxyethyl)thio]propan-2-ol - boundary composition
- Type of composition:
- boundary composition of the substance
- Reference substance:
- 1-[(2-hydroxyethyl)thio]propan-2-ol - boundary composition
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Persistence
In accordance with Annexes VII and VIII of REACH a ready biodegradability study was performed on the registered substance according to the OECD Testing Guideline 301D. This study concluded that the substance was not ready biodegradable.
Since 1-[(2-hydroxyethyl)thio]propan-2-ol is not B, vB or T it is not considered relevant to further investigate the P properties of the registered substance and therefore to perform further biodegradation testing.
Bioaccumulation
The Log Kow of 1-[(2-hydroxyethyl)thio]propan-2-ol was calculated using a valid QSAR model (KOWWIN V1.68). The substance and the prediction fall within the applicability domain of the model and the result is therefore considered as acceptable. The QSAR model determined a Log Kow = -0.2. This result is below 4.5 therefore 1-[(2-hydroxyethyl)thio]propan-2-ol is not considered to demonstrate bioaccumulation potential.
The substance does not meet the B or vB criteria.
Toxicity
In accordance with Annexes VII and VIII of REACH no chronic toxicity testing to the aquatic environment was performed on the registered substance. Short-term toxicity of 1-[(2-hydroxyethyl)thio]propan-2-ol to aquatic invertebrates, algae, and fish was investigated and none of the resulting L(E)C50 result was below 100 mg/L. The substance did not meet the criteria for classification as toxic to the aquatic environment according to Regulation (EC) N° 1272/2008.
Based on the available information on the registered substance it can be concluded that 1-[(2-hydroxyethyl)thio]propan-2-ol does not meet the criteria for classification as mutagenic, toxic to reproduction, or toxic to specific organs following a repeated exposure according to Regulation (EC) N° 1272/2008. No data is available on the carcinogenicity of the substance and there is no requirement in Annexes VII and VIII of REACH to investigate this endpoint.
The substance does not meet the T criteria.
Conclusion
1-[(2-hydroxyethyl)thio]propan-2-ol does not meet the PBT and the vPvB criteria. It is not considered relevant to further investigate the PBT or vPvB properties of the substance.
Reference
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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