Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 229-765-0 | CAS number: 6713-03-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
An assessment of the hydrolysis of 1-[(2-Hydroxyethyl)thio]propan-2-ol was performed based on the molecular structure of the substance as well as the available data on the physico-chemical properties of the substance and those of similar substances. It concluded that 1-[(2-Hydroxyethyl)thio]propan-2-ol is hydrolytically stable under the pH and temperature conditions of physiological and environmental relevance.
An assessment was performed to determine the soil adsorption coefficient (Koc) of 1-[(2-hydroxyethyl)thio]propan-2-ol. It included a literature search that allowed to identify suitable information and data relating to the substance. A KOWWIN V1.68 QSAR prediction rendered a log Kowvalue of -0.20, and based on the composition of 1-[(2-hydroxyethyl)thio]propan-2-ol, it is considered appropriate to estimate the soil sorption of the substance from the octanol-water partition coefficient (Kow). A substance is regarded by SETAC (1993): Guidance Document on Sediment Toxicity Tests and Bioassays for Freshwater and Marine Environments as having the potential for adsorption if its log10 Kocor log10 Kowis⩾3. As 1-[(2-hydroxyethyl)thio]propan-2-ol has a log Kowof -0.20 that is below 3, the substance is expected to have a low potential for adsorption and, therefore, additional adsorption-desorption data is not required under REACH Annex VIII. Any sorption of 1-[(2-hydroxyethyl)thio]propan-2-ol] to soil or sediment will be negligible.
The ready biodegradation of 1-[(2-hydroxyethyl)thio]propan-2-ol in an aerobic aqueous environment was determined in line with OECD Guideline 301 D - Ready Biodegradability: Closed Bottle Test. The study satisfied all validity criteria and a minor deviation, in which no valid microbial count could be obtained for aged inoculum, was not believed to have had an effect on the final result. After 28 days, percentage biodegradation of 1-[(2-hydroxyethyl)thio]propan-2-ol was report as 15 % (based on O2 consumption). This result did not achieve the pass removal level of 60 % of theoretical maximum within the 10 (or 14) day window. It is possible to conclude, therefore, that 1-[(2-hydroxyethyl)thio]propan-2-ol is not readily biodegradable under test conditions.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.