Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 216-544-9 | CAS number: 1609-86-5
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The acute toxicity of tert.-Butylamine, the hydrolysis product of tert-butyl isocyanate, to fish was tested according to OECD TG 203. After 96 hours of exposure a LC50 of >500 mg/L was obtained.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 500 mg/L
Additional information
read-across to the corresponding amine
Read-Across-Justification:
Isocyanates are known to rapidly hydrolyse under the formation of the corresponding amine as well as solid polyurea compounds *. However, the insoluble inert polyurea is not assumed to cause environmental hazards due to the reduced uptake of high molecular mass compounds, whereas the amine is assumed to be the ecotoxicological relevant species. Concluding, tests per-formed using the corresponding amine can equally be used to assess the ecotoxicological hazards of isocyanates assuming the complete transfer of the isocyanate into the corresponding amine while neglecting the formation of a certain fraction ecotoxicological not active polyurea com-pounds. An underestimation of environmental hazards is thus avoided supporting a conservative and thus protective hazard assessment.
* Test Lab (2004). 4-chlorophenyl-isocyanate: Investigation on Stability in Aque-ous Test Solutions. Project No: 200300181.
Test Lab
(2003). Isopropylisocyante: Investigation on Stability in Aqueous Test Solutions. Project No: 200300095.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
