Registration Dossier
Registration Dossier
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EC number: 202-426-4 | CAS number: 95-51-2
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given (comparable to guidelines/standards)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Quantitative structure-activity relationships and mixture toxicity studies of chloro- and alkylanilines at an acute lethal toxicity level to the guppy (Poecilia reticulata)
- Author:
- Hermens J, Leeuwangh P, Musch A
- Year:
- 1 984
- Bibliographic source:
- Ecotoxicology and Environmental Safety 8, 388-394
- Reference Type:
- other: BUA Report
- Title:
- Unnamed
- Year:
- 1 991
- Reference Type:
- publication
- Title:
- Quantitative structure-activity relationships in fish toxicity studies
- Author:
- Koenemann H
- Year:
- 1 981
- Bibliographic source:
- Toxicology 19, 209-221
Materials and methods
- Principles of method if other than guideline:
- open system (but covered with glass plate), semi-static
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-chloroaniline
- EC Number:
- 202-426-4
- EC Name:
- 2-chloroaniline
- Cas Number:
- 95-51-2
- Molecular formula:
- C6H6ClN
- IUPAC Name:
- 2-chloroaniline
Constituent 1
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- stock solution in 2-propanol;
standard test water according to Alabaster and Abram
Test organisms
- Test organisms (species):
- Poecilia reticulata
- Details on test organisms:
- age: 2-3 months;
feeding: daily
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Total exposure duration:
- 14 d
Test conditions
- Hardness:
- 25 mg/L (CaCO3)
- Test temperature:
- 22 +/- 1 °C
- Dissolved oxygen:
- <5 mg/L
- Details on test conditions:
- standard test water according to Alabaster and Abram;
open test system (but covered with a glass plate;
daily water renewal;
more details on test conditions: see Koenemann (1981)
Results and discussion
Effect concentrations
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- 6.25 mg/L
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
