Registration Dossier
Registration Dossier
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EC number: 201-756-6 | CAS number: 87-60-5
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary literature available
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Chlortoluidine (3-Chlor-2-methylanilin, 5-Chlor-2-methylanilin, 3-Chlor-4-methylanilin)
- Author:
- Gesellschaft Deutscher Chemiker
- Year:
- 1 990
- Bibliographic source:
- Beratergremium für umweltrelevante Altstoffe (BUA), BUA-Stoffbericht 55
- Reference Type:
- publication
- Title:
- Do induced sperm-head abnormalities in mice specifically identify mammalian mutagens rather than carcinogens?
- Author:
- J.C. Topham
- Year:
- 1 980
- Bibliographic source:
- Mutat. Res. 74, pp. 379-387
Materials and methods
- Principles of method if other than guideline:
- Sperm abnormality test in mice. Application of the test substance intraperitoneally on 5 consecutive days. 5 weeks after last application analysis of sperm morphology.
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- 5-chloro-o-toluidine
- EC Number:
- 202-452-6
- EC Name:
- 5-chloro-o-toluidine
- Cas Number:
- 95-79-4
- Molecular formula:
- C7H8ClN
- IUPAC Name:
- 5-chloro-2-methylaniline
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: (CB [male] x Balb/c [female])F1
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- corn oil
- Details on exposure:
- Application of 5mL/kg bw/day
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 5 consecutive days
- Frequency of treatment:
- daily
- Duration of test:
- 5 weeks and 5 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
50, 100, 250, and 500 mg/kg bw/day
Basis:
no data
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- Five weeks after the last application the sperm was analyzed for abnormal sperm heads.
Results and discussion
Observed effects
No increase of the number of abnormal sperms were induced through the test substance in all other groups.
Applicant's summary and conclusion
- Conclusions:
- An application of the test substance intraperitoneally for 5 consecutive days did not induce a change in sperm morphology. At 500 mg/kg bw/day all mice died.
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