Registration Dossier
Registration Dossier
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EC number: 201-756-6 | CAS number: 87-60-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary literature
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Chlortoluidine (3-Chlor-2-methylanilin, 5-Chlor-2-methylanilin, 3-Chlor-4-methylanilin)
- Author:
- Gesellschaft deutscher Chemiker
- Year:
- 1 990
- Bibliographic source:
- Beratergremium für umweltrelevante Altstoffe (BUA), BUA-Stoffbericht 55
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-chloro-p-toluidine
- EC Number:
- 202-446-3
- EC Name:
- 3-chloro-p-toluidine
- Cas Number:
- 95-74-9
- IUPAC Name:
- 3-chloro-4-methylaniline
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- polyethylene glycol
- Details on dermal exposure:
- TEST SITE
- Area of exposure: abdomen - Duration of exposure:
- 4 hours or 7 days
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 765 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 4 hour application
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 336 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 7 day application
- Mortality:
- Animals died within one to two days.
- Clinical signs:
- other: Cyanosis, labor respiration and sedation was seen 6 hours after application. Animals which did not die recovered within 4 to 7 days.
- Other findings:
- The highest dose tested without lethal effects was 118 mg/kg bw and the highest dose without symptoms was 59 mg/kg bw.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
