Registration Dossier
Registration Dossier
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EC number: 401-990-0 | CAS number: 106990-43-6 CHIMASSORB 119; LOWILITE 19
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: information from migrated NONS file as per inquiry # [06-0000014790-71-0000], permission to refer granted by ECHA
Data source
Reference
- Reference Type:
- other: body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V B7
- GLP compliance:
- yes
Test material
- Reference substance name:
- N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine
- EC Number:
- 401-990-0
- EC Name:
- N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine
- Cas Number:
- 106990-43-6
- Molecular formula:
- C132H250N32
- IUPAC Name:
- N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine
Constituent 1
Test animals
- Species:
- other: Wistar rat, KFM Han, outbred SPF-quality
Administration / exposure
- Route of administration:
- oral: unspecified
- Details on oral exposure:
- Diet
- Duration of treatment / exposure:
- 28 days
- No. of animals per sex per dose:
- Male: 5 animals at 0mg/kg bw/day
Male: 5 animals at 33mg/kg bw/day
Male: 5 animals at 134mg/kg bw/day
Male: 5 animals at 750mg/kg bw/day
Female: 5 animals at 0mg/kg bw/day
Female: 5 animals at 35mg/kg bw/day
Female: 5 animals at 140mg/kg bw/day
Female: 5 animals at 760mg/kg bw/day
Results and discussion
Results of examinations
- Details on results:
- Clinical observations: No death occur.
Body weight gains were reduced for both sexes of group 4 (15% males and approximately 5% for females relative to respective controls)
Lab findings: Haematology: the changes observed were not considered to be significant in toxicological terms.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Not classified
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