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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin sensitisation
Remarks:
in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: information from migrated NONS file as per inquiry # [06-0000014790-71-0000], permission to refer granted by ECHA

Data source

Reference
Reference Type:
other: body responsible for the test
Title:
Unnamed
Year:
2011

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Maximization test according to Magnusson and Kligman Annex V B6
GLP compliance:
yes
Type of study:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine
EC Number:
401-990-0
EC Name:
N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine
Cas Number:
106990-43-6
Molecular formula:
C132H250N32
IUPAC Name:
N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine

In vivo test system

Test animals

Species:
other: albino guinea pig
Strain:
other: Pirbright white strain DHP

Study design: in vivo (non-LLNA)

Induction
Concentration / amount:
First induction (intrademal injection): 1% in Sesame oil and adjuvant saline mixture.
Second induction (epidermal application): 10% in vaseline

concentration of test material and vehicle used for each challenge: 0.3% in vaseline
Challenge
Concentration / amount:
First induction (intrademal injection): 1% in Sesame oil and adjuvant saline mixture.
Second induction (epidermal application): 10% in vaseline

concentration of test material and vehicle used for each challenge: 0.3% in vaseline
No. of animals per dose:
Number of animals in test group: 20
Number of animls in negative control group: 10

Results and discussion

In vivo (non-LLNA)

Results
Reading:
other: n/a
Group:
test chemical
Dose level:
n/a
No. with + reactions:
10
Total no. in group:
20
Remarks on result:
other: Reading: other: n/a. Group: test group. Dose level: n/a. No with. + reactions: 10.0. Total no. in groups: 20.0.

Applicant's summary and conclusion

Interpretation of results:
sensitising
Remarks:
Migrated information Criteria used for interpretation of results: EU