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EC number: 204-485-1 | CAS number: 121-60-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary source.
Data source
Reference
- Reference Type:
- other: Secondary Source
- Title:
- Acute Oral Toxicity Study in rats
- Author:
- NTRL
- Year:
- 1 991
- Bibliographic source:
- NTRL_121608
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Equivalent or similar to OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- N-acetylsulphanilyl chloride
- EC Number:
- 204-485-1
- EC Name:
- N-acetylsulphanilyl chloride
- Cas Number:
- 121-60-8
- Molecular formula:
- C8H8ClNO3S
- IUPAC Name:
- 4-acetamidobenzenesulfonyl chloride
- Test material form:
- not specified
- Details on test material:
- Name: 4-(Acetylamino)benzenesulfonyl chloride
CAS No.: 121-60-8
Molecular Formula: C8-H8-Cl-N-O3-S
Molecular Weight: 233.6742 g/mol
SMILES: CC(=O)Nc1ccc(cc1)S(=O)(=O)Cl
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No Data Available
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 2 % NaCS
- Details on oral exposure:
- No Data Available
- Doses:
- 50-3200 mg/kg bw
- No. of animals per sex per dose:
- 3 rats per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: No Data Available
- Necropsy of survivors performed: No Data Available
- Clinical signs including body weight : Yes
- Other examinations performed: clinical signs, body weight - Statistics:
- No Data Available
Results and discussion
- Preliminary study:
- No Data Available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 3 200 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- No mortality was observed after administration of the test chemical till 3200 mg/kg bw.
- Clinical signs:
- Clinical signs of normal to moderate weakness and vasodilation in one animals was observed. Ataxia was also observed.
- Body weight:
- Normal body weight gain was observed in all the animals.
- Gross pathology:
- No Data Available
- Other findings:
- No Data Available
Applicant's summary and conclusion
- Interpretation of results:
- other: Not Classified as per the CLP criteria of classification and labeling.
- Conclusions:
- Based on all the observations and results, it was concluded that the test chemical did not cause any mortalities when test chemical was administered orally to three rats at 3200 mg/kg bw. Therefore, the test chemical is not likely to classify as a toxicant as per the CLP criteria of classification and labeling.
- Executive summary:
An acute oral toxicity study using the test chemical was performed using 3 animals per dose. The test chemical was administered to the rats from dose ranging from 50-3200 mg/kg bw. The test chemical was dissolved in 2% NaCS in to prepare 10% solution of the suspension. The animals were observed for 14 days, for any mortalities, clinical signs and changes in body weights. It was observed that there were no mortalities during the observation period till 3200 mg/kg bw. A few clinical signs of normal to moderate weakness and vasodilation in one animals was observed. Ataxia was also observed. Normal body weight gain was observed in all the animals. Thus, based on all the observations and results, it was concluded that the test chemical did not cause any mortalities when test chemical was administered orally to three rats at 3200 mg/kg bw. Therefore, the test chemical is not likely to classify as a toxicant as per the CLP criteria of classification and labeling.
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