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EC number: 204-485-1 | CAS number: 121-60-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute Oral Toxicity:
Based on all the available data on the test chemical and also from the observations and results, it was concluded that the test chemical did not cause any mortalities, at doses above 2000 mg/kg bw and therefore is not likely to classify as a toxicant as per the CLP criteria of classification and labelling.
Acute Dermal Toxicity:
An acute dermal toxicity study does not need to be conducted since the pH of the test chemical is 1.97, which indicates the test chemical is highly acidic in nature and is likely to be classified in 'Skin irritant Category 1' as per CLP criteria of classifcation and labeling. Therfore, this endpoint is considered as a 'Waiver'.
Acute Inhalation Toxicity:
An acute inhalation toxicity study does not need to be conducted because exposure of humans via inhalation in production and/or use is not likely as based on the provided thorough and rigorous exposure assessment. Also, the given test chemical has very low vapor pressure 3.34E-007 mmHg at 25°C., so the potential for the generation of inhalable vapors is very low. The normal conditions of use of this substance will not result in aerosols, particles or droplets of an inhalable size, so exposure to humans via the inhalatory route will be highly unlikely and therefore this end point for repeated inhalation toxicity was considered for waiver.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary source.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Equivalent or similar to OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No Data Available
- Route of administration:
- oral: gavage
- Vehicle:
- other: 2 % NaCS
- Details on oral exposure:
- No Data Available
- Doses:
- 50-3200 mg/kg bw
- No. of animals per sex per dose:
- 3 rats per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: No Data Available
- Necropsy of survivors performed: No Data Available
- Clinical signs including body weight : Yes
- Other examinations performed: clinical signs, body weight - Statistics:
- No Data Available
- Preliminary study:
- No Data Available
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 3 200 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- No mortality was observed after administration of the test chemical till 3200 mg/kg bw.
- Clinical signs:
- Clinical signs of normal to moderate weakness and vasodilation in one animals was observed. Ataxia was also observed.
- Body weight:
- Normal body weight gain was observed in all the animals.
- Gross pathology:
- No Data Available
- Other findings:
- No Data Available
- Interpretation of results:
- other: Not Classified as per the CLP criteria of classification and labeling.
- Conclusions:
- Based on all the observations and results, it was concluded that the test chemical did not cause any mortalities when test chemical was administered orally to three rats at 3200 mg/kg bw. Therefore, the test chemical is not likely to classify as a toxicant as per the CLP criteria of classification and labeling.
- Executive summary:
An acute oral toxicity study using the test chemical was performed using 3 animals per dose. The test chemical was administered to the rats from dose ranging from 50-3200 mg/kg bw. The test chemical was dissolved in 2% NaCS in to prepare 10% solution of the suspension. The animals were observed for 14 days, for any mortalities, clinical signs and changes in body weights. It was observed that there were no mortalities during the observation period till 3200 mg/kg bw. A few clinical signs of normal to moderate weakness and vasodilation in one animals was observed. Ataxia was also observed. Normal body weight gain was observed in all the animals. Thus, based on all the observations and results, it was concluded that the test chemical did not cause any mortalities when test chemical was administered orally to three rats at 3200 mg/kg bw. Therefore, the test chemical is not likely to classify as a toxicant as per the CLP criteria of classification and labeling.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 200 mg/kg bw
- Quality of whole database:
- Data is from a Klimisch 4 database but provides a robust study summary for classification and labeling of the test chemical.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- exposure considerations
- Justification for data waiving:
- the study does not need to be conducted because exposure of humans via inhalation is not likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Quality of whole database:
- The study is considered as a waiver.
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is classified as corrosive to the skin
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Quality of whole database:
- The study is considered to be a waiver.
Additional information
Acute Oral Toxicity:
The available data for the test chemical for acute oral toxicity study is as follows:
Study 1:
An acute oral toxicity study using the test chemical was performed using 3 animals per dose. The test chemical was administered to the rats from dose ranging from 50-3200 mg/kg bw. The test chemical was dissolved in 2% NaCS in to prepare 10% solution of the suspension. The animals were observed for 14 days, for any mortalities, clinical signs and changes in body weights. It was observed that there were no mortalities during the observation period till 3200 mg/kg bw. A few clinical signs of normal to moderate weakness and vasodilation in one animals was observed. Ataxia was also observed. Normal body weight gain was observed in all the animals. Thus, based on all the observations and results, it was concluded that the test chemical did not cause any mortalities when test chemical was administered orally to three rats at 3200 mg/kg bw. Therefore, the test chemical is not likely to classify as a toxicant as per the CLP criteria of classification and labeling.
Study 2:
The acute oral toxicity study according to OECD test guideline 423 of the test chemical in rats showed that this chemical did not cause any significant changes in terms of LD50 at 2,000 mg/kg b.w for 1st and 2nd steps, and 5,000 mg/kg bw for limit test. Based on all the observations and results, it was concluded that the test chemical did not cause any mortalites when tested at the doses of 2000 and 5000 mg/kg bw, therefore the LD50 of the test chemical is considered to be greater than 5000 mg/kg and the test chemical was not classified as per the CLP criteria of classification and labeling.
Study 3:
An acute oral toxicity study, equivalent or similar to OECD test guideline 401, was conducted to assess the toxicity potential of the test chemical after single administration to Sprague Dawley rats. The test chemical was suspended in the corn oil to prepare a 20% suspension-solution. 5 animals per sex per dose were allocated. The doses 3980, 5010, 6310 and 7940 mg/kg bw were selected for the study. No mortality was observed at 3980 mg/kg bw while mortalities due to administration of the test chemical was observed from 5010, 6310 and 7940 mg/kg bw. Clinical signs included reduced appetite and activity (one to three days in survivors), increasing weakness, slight tremors, and death. Lung and liver hyperplasia, and acute gastrointestinal inflammation was observed in animals that died. Viscera appeared normal for all surviving animals. No changes in the body weights were observed. Therefore, based on all the observations and results, it was concluded that the LD50 value of the test chemical was greater than 2000 mg/kg bw (> 5300 mg/kg bw), as observed in the study. Thus, the test chemical is not likely to classify as a toxicant as per the CLP criteria of classification and labeling.
Acute Dermal Toxicity:
An acute dermal toxicity study does not need to be conducted since the pH of the test chemical is 1.97, which indicates the test chemical is highly acidic in nature and is likely to be classified in 'Skin irritant Category 1' as per CLP criteria of classifcation and labeling. Therfore, this endpoint is considered as a 'Waiver'.
Acute Inhalation Toxicity:
An acute inhalation toxicity study does not need to be conducted because exposure of humans via inhalation in production and/or use is not likely as based on the provided thorough and rigorous exposure assessment. Also, the given test chemical has very low vapor pressure 3.34E-007 mmHg at 25°C., so the potential for the generation of inhalable vapors is very low. The normal conditions of use of this substance will not result in aerosols, particles or droplets of an inhalable size, so exposure to humans via the inhalatory route will be highly unlikely and therefore this end point for repeated inhalation toxicity was considered for waiver.
Justification for classification or non-classification
Based on all the available data on the test chemical, it was concluded that the test chemical was not likely to cause adverse effects via oral and dermal route, while the exposure of the test chemical via inhalation route was not possible. Therefore, the test chemical is not likely to classify as a toxicant via oral, dermal and inhalation route as per the CLP criteria of classification and labeling.
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