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Diss Factsheets

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
bioaccumulation in aquatic species, other
Remarks:
aquatic organisms
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from HSDB and PubChem authoritative database
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Environmental bioconcentration factor of the test substance in aquatic organisms was estimated using a log Kow and a regression-derived equation.
GLP compliance:
not specified
Radiolabelling:
not specified
Vehicle:
not specified
Test organisms (species):
other: Aquatic organisms
Route of exposure:
aqueous
Test type:
not specified
Water / sediment media type:
natural water: freshwater
Reference substance (positive control):
not specified
Details on estimation of bioconcentration:
BASIS FOR CALCULATION OF BCF
- Result based on calculated log Pow of: 2.94
Type:
BCF
Value:
24 dimensionless
Basis:
whole body w.w.
Calculation basis:
other: BCF value of test chemical was estimated using a log Kow and a regression-derived equation.
Remarks on result:
other: Other details not known

According to classification scheme, the BCF value of test chemical suggests that the potential for bioconcentration in aquatic organisms is low.

Validity criteria fulfilled:
not specified
Conclusions:
The estimated BCF (bioaccumulation factor) of test chemical in aquatic organisms was determined to be 24 dimensionless.
Executive summary:

The bioaccumulation study in aquatic organisms was conducted for estimating the BCF (bioaccumulation factor) value of test chemical. The bioaccumulation factor (BCF) value was calculated using a log Kow of 2.94 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 24 dimensionless, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is considered to be non-bioaccumulative in aquatic organisms.

Description of key information

The bioaccumulation study in aquatic organisms was conducted for estimating the BCF (bioaccumulation factor) value of test chemical. The bioaccumulation factor (BCF) value was calculated using a log Kow of 2.94 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 24 dimensionless, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is considered to be non-bioaccumulative in aquatic organisms.

Key value for chemical safety assessment

BCF (aquatic species):
24 dimensionless

Additional information

Experimental studies for test chemical and its structurally similar read across chemical have been reviewed for bioaccumulation endpoint and their results are summarized below.

First study was reveiwed from authoritative database ( HSDB, 2017) in this study the the bioaccumulation factor (BCF) value was calculated using a log Kow of 2.94 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 24 dimensionless, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is considered to be non-bioaccumulative in aquatic organisms.

Another study was reviewed from authoritative database (J check) in this study the Bioaccumulation test was conducted for 6 weeks for determination the bioconcentration factor (BCF) of test chemical on test organism Cyprinus carpio. Recovery ratio : Test water : 1st concentration area : 90.1 %, 2nd concentration area : 79.6 %, Fish : 92.7 %, - Limit of detection : Fish : 0.

ppm And Nominal concentrations used in the study as - 1st Concentration area: 0.0001 mg/L, 2nd Concentration area : 0.00001 mg/L and Range finding study was carried out on Rice fish (Oryzias latipes) TLm(48h) 6.4 ppm(w/v), Rice fish (Oryzias latipes).Thus according to static Fish test the bioconcentration factor (BCF) for test chemical was determined according static fish test. The BCF value was observed to be 16-21 L/kg at dose concentration 0.0001 mg/L and 8.1-18 L/kg at dose concentration 0.00001 mg/L on test organism Cyprinus carpio during 6 weeks period.Therefore it is concluded that this test chemical is nonbioaccumulative.

In last study the BCF value of test chemical was estimated is 57 dimensionless by using log Kow of 3.50 and regression derived equation and it is far less than 2000 so it is concluded that this chemical is non bioaccumulative.

By considering results of all the studies mentioned above it can be concluded that test chemical is non-bioaccumulative in nature.