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Diss Factsheets
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EC number: 215-385-2 | CAS number: 1324-76-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In vitro
There were three in vitro gene mutation studies in bacteria (i.e. Salmonella typhimurium and Escherichia coli) was conducted in Experimental Toxicology and Ecology BASF, (Project No.: 40M0437/034091, 034092, 034093). Test article was applied at dose level up to 2500 µg/plate. An increase in the number of his+or trp+revertants was not observed in the standard plate test or in the preincubation test either without S-9 mix or after the addition of a metabolizing system. Based on the results of these studies, test article is not mutagenic in the Salmonella typhimurium/Escherichia coli reverse mutation assay.
In addition, one mouse lymphoma forward mutation assay(Dr. rer. nat. C. Flügge, report no. 28832) following OECD guideline 476 was conducted to assess the ability of the test item to induce forward mutations at the thymidine kinase (TK) locus in L5178Y TK +/- mouse lymphoma cells as assayed by colony growth in the presence of 5-trifluorothymidine (TFT).Based on the results of this study, test article in the absence and presence of metabolic activation in two independent experiments was negative with respect to the mutant frequency in the L5178Y TK +/- mammalian cell mutagenicity test. In addition, no change was noted in the ratio of small to large mutant colonies. Therefore, test article also did not exhibit clastogenic potential at the concentration-range investigated.
In vivo
An in vivo cytogenicity toxicity study( Dr. W. Müller, report no.: 94.0363) was performed to according to OECD guideline No. 474 with GLP to investigate the clastogenic potential of test article dosed once orally at level of 2000 mg/kg body weight to male and female mice. The animals were killed 12, 24, or 48 hours after administration. The ratio of polychromatic erythrocytes to normocytes was not changed to a significant extent by the treatment with test article and not different from the control values.
According to Chapter R.7a: Endpoint specific guidance, table R.7.7-5, row 9, no further tests are required since available data (negative results as above) is sufficient to conclude that test article is non-mutagenicy.
Short description of key information:
Based on the available information, test article can be considered non-mutagenicity.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on available data, test article can not be classified according to CLP(Regulation No.1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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