Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 500-394-9 | CAS number: 157707-87-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral (OECD 401), rat (m/f): LD50 > 2000 mg/kg bw (limit test)
Dermal (OECD 402), rabbit (m/f): LD50 > 2000 mg/kg bw (limit test), based on read-across
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- The available information comprises an adequate and reliable study (Klimisch score 2) and one disregarded study (Klimisch score 4).
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- The available information comprises an adequate and reliable study (Klimisch score 2) and one disregarded study (Klimisch score 4).
Additional information
There is only limited data available on the acute dermal toxicity of D-Glucopyranose, oligomers, branched and linear C9-11-alkyl glycosides. In order to fulfil the standard information requirements set out in Annex VIII, 8.5, in accordance with Annex XI, 1.5, of Regulation (EC) No 1907/2006, read-across from structurally related substance is conducted following a category approach.
A detailed justification for the grouping of chemicals and read-across is provided in the technical dossier (see IUCLID Sections 7.1 and 13).
Oral
Two acute oral toxicity studies in rats are available for D-Glucopyranose, oligomers, branched and linear C9-11-alkyl glycosides (CAS 157707-87-4). In the key study, 5 male and 5 female Sprague Dawley rats were exposed to a limit dose of 2000 mg/kg bw according to OECD guideline 401 (Drug Safety Testing Center, 1988). No mortality and no adverse effects were observed up to the end of the 14-day observation period. Based on the results of the study, the oral LD50 value for male and female rats was greater than 2000 mg/kg bw.
In another study, which was performed equivalent or similar to OECD guideline 401, treatment with the test substance at limit dose resulted in a LD50 greater than 2000 mg/kg bw in male and female rats, and thus supports the findings of the key study (Zeneca, 1993).
Dermal
There is only limited data available on the acute dermal toxicity of D-Glucopyranose, oligomers, branched and linear C9-11-alkyl glycosides (CAS 157707-87-4). An insufficiently documented study in male and female rats revealed no signs of systemic toxicity at a dose of 2000 mg/kg bw (ICI Central, 1993).
However, two reliable studies for the category members D-Glucopyranose, oligomeric, C10-16-alkyl glycosides and D-Glucopyranose, oligomers, decyl octyl glycosides (CAS 68515-73-1) exist, which were used for read-across based on the category approach. Both studies were performed according to OECD guideline 402 and in compliance with GLP.
In the acute dermal toxicity study with D-Glucopyranose, oligomeric, C10-16-alkyl glycosides, the test substance was applied at a limit dose of 2000 mg/kg bw on the skin of 5 male and 5 female New Zealand White rabbits for 24 h. Clinical signs of partly hunched posture and slight depression occurred during the observation period. No mortality and no adverse effects including those on the skin were observed during the study period. Therefore, the dermal LD50 value of the test substance for male and female rabbits was greater than 2000 mg/kg bw (Hill Top Biolabs, 1989).
In a similar study performed with the category member D-Glucopyranose, oligomers, decyl octyl glycosides, no substance-related mortalities were observed after dermal application of the test substance at a limit dose of 2000 mg/kg bw in male and female New Zealand White rabbits. Test substance-related clinical changes of emaciation (2/5), nasal discharge (3/5), faecal stains (5/5), yellow area throughout the site of application (5/5) and lacrimation (1/5) occurred in the animals. Irritative effects on the skin in the form of moderate to marked erythema, mild to moderate edema, atopy, desquamation, and mild coriaceousness were most frequently observed within the animals. Based on the result of this study, the dermal LD50 value of the test substance for male and female rabbits was greater than 2000 mg/kg bw (Hill Top Biolabs, 1987).
Inhalation
This information is not available. The substance has a low vapour pressure and is marketed in aqueous formulation; therefore, human exposure to vapours or dusts is not to be expected. In addition, reliable data from studies with the substance itself for acute toxicity via the oral and dermal route and from studies performed with structurally related substances according to Regulation (EC) No. 1907/2006, Annex XI, article 1.5 via the dermal route are available.
Justification for selection of acute toxicity – oral endpoint
The selected study is the most adequate and reliable study based on overall quality assessment.
Justification for selection of acute toxicity – inhalation endpoint
No study required since the substance has a low vapour pressure and is marketed in liquid form; therefore, human exposure to vapours or dusts is not to be expected.
Justification for selection of acute toxicity – dermal endpoint
The selected study is the most adequate and reliable study based on overall quality assessment.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.