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EC number: 500-394-9 | CAS number: 157707-87-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions. Conducted with 6 animals according to previous version of guideline adopted in 1987. No English translation available.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- conducted with 6 animals according to previous version of guideline adopted in 1987
- GLP compliance:
- no
Test material
- Reference substance name:
- D-Glucopyranose, oligomers, branched and linear C9-11-alkyl glycosides
- EC Number:
- 500-394-9
- EC Name:
- D-Glucopyranose, oligomers, branched and linear C9-11-alkyl glycosides
- Cas Number:
- 157707-87-4
- Molecular formula:
- not applicable, UVCB substance
- IUPAC Name:
- not applicable, UVCB substance
- Details on test material:
- - Name of test material (as cited in study report): No data
- Physical state: No data
- Analytical purity: 50% AS
- Lot/batch No.: AM-BS
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Japanese white rabbit
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Sankyo Labo Service
- Age at study initiation: 14 weeks
- Weight at study initiation: 2.75-3.12kg
- Housing: single
- Diet: RC4, ad libitum
- Water: tap water, ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23 ± 2
- Humidity (%): 50 ± 10
- Air changes (per hr): 17
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- other: phosphate buffered saline 1/15M pH 7.2
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.1 mL
- Concentration: 100% (w/v) (50% AS), 30% (w/v) (15% AS), 3% (w/v) (1.5% AS) - Duration of treatment / exposure:
- 30 s or single application without washing
- Observation period (in vivo):
- 21 days
reading time points: 1, 3, 6, 24, 48, 72 h and 4, 7, 14 and 21 days - Number of animals or in vitro replicates:
- 9 animals/concentration (3 animals rinsed, 6 animals not-rinsed)
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: yes, 3 animals per concentration (lukewarm water 300 mL)
- Time after start of exposure: 30 s
SCORING SYSTEM: Draize scoring system
TOOL USED TO ASSESS SCORE: 2% fluorescein sodium solution
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- other: mean after 24/48/72 h
- Score:
- 1.2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 50% AS
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- other: mean after 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: reversibility: not applicable
- Remarks on result:
- other: 50% AS
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- other: mean after 24/48/72 h
- Score:
- 1.2
- Max. score:
- 3
- Reversibility:
- fully reversible within: 14 days
- Remarks on result:
- other: 50% AS
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- other: mean after 24/48/72 h
- Score:
- 1.2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Remarks on result:
- other: 50% AS
- Other effects:
- No further local or systemic effects were observed.
Any other information on results incl. tables
Table 1: Result of Alkyl polyglucoside eye irritation test in rabbit
sample: 100% (w/w) (50% AS), 0.1 mL, instillation
group | animal No. |
sex | body weight (kg) |
observation time (h) | day after instillation | ||||||||
1 | 3 | 6 | 1 | 2 | 3 | 4 | 7 | 14 | 21 | ||||
rinse group |
1 | female | 3.10 | 10 | 10 | 10 | 14 | 12 | 6 | 6 | 6 | 0 | 0 |
2 | female | 2.75 | 10 | 10 | 10 | 12 | 6 | 4 | 2 | 0 | 0 | 0 | |
3 | female | 2.95 | 14 | 14 | 14 | 14 | 6 | 4 | 2 | 0 | 0 | 0 | |
mean | 11.3 | 11.3 | 11.3 | 13.3 | 8.0 | 4.7 | 3.3 | 2.0 | 0.0 | 0.0 | |||
I.A.O.I | 13.3 | ||||||||||||
no-rinse group |
4 | female | 2.90 | 14 | 14 | 14 | 12 | 52 | 52 | 48 | 46 | 32 | 30 |
5 | female | 3.12 | 12 | 12 | 12 | 8 | 28 | 44 | 46 | 46 | 20 | 20 | |
6 | female | 2.79 | 14 | 14 | 12 | 10 | 50 | 48 | 48 | 26 | 0 | 0 | |
7 | female | 2.80 | 14 | 14 | 12 | 8 | 48 | 48 | 28 | 22 | 0 | 0 | |
8 | female | 2.89 | 14 | 14 | 10 | 8 | 28 | 48 | 28 | 2 | 0 | 0 | |
9 | female | 2.91 | 14 | 14 | 12 | 8 | 28 | 46 | 46 | 42 | 62 | 80 | |
mean | 13.7 | 13.7 | 12.0 | 9.0 | 39.0 | 47.7 | 40.7 | 30.7 | 19.0 | 21.7 | |||
I.A.O.I | 47.7 |
sample: 30% (w/v) (15% AS), 0.1 mL, instillation
group | animal No. |
sex | body weight (kg) |
observation time (h) | day after instillation | ||||||||
1 | 3 | 6 | 1 | 2 | 3 | 4 | 7 | 14 | 21 | ||||
rinse group |
10 | female | 2.90 | 10 | 10 | 10 | 8 | 2 | 0 | 0 | 0 | - | - |
11 | female | 2.91 | 10 | 10 | 10 | 12 | 4 | 2 | 0 | 0 | - | - | |
12 | female | 2.85 | 10 | 10 | 10 | 12 | 4 | 0 | 0 | 0 | - | - | |
mean | 10.0 | 10.0 | 10.0 | 10.7 | 3.3 | 0.7 | 0.0 | 0.0 | - | - | |||
I.A.O.I | 10.7 | ||||||||||||
no-rinse group |
13 | female | 2.99 | 10 | 10 | 10 | 6 | 4 | 24 | 22 | 0 | 0 | 0 |
14 | female | 2.76 | 10 | 10 | 10 | 10 | 10 | 8 | 6 | 6 | 2 | 0 | |
15 | female | 2.75 | 10 | 10 | 12 | 12 | 6 | 2 | 2 | 0 | 0 | 0 | |
16 | female | 2.95 | 10 | 10 | 10 | 6 | 26 | 24 | 2 | 0 | 0 | 0 | |
17 | female | 2.99 | 10 | 10 | 10 | 10 | 8 | 4 | 4 | 0 | 0 | 0 | |
18 | female | 2.91 | 12 | 12 | 12 | 6 | 4 | 4 | 4 | 0 | 0 | 0 | |
mean | 10.3 | 10.3 | 10.7 | 8.3 | 9.7 | 11.0 | 6.7 | 1.0 | 0.3 | 0.0 | |||
I.A.O.I | 11.0 |
sample: 3% (w/v) (1.5% AS), 0.1 mL, instillation
group | animal No. |
sex | body weight (kg) |
observation time(hr) | day after instillation | ||||||||
1 | 3 | 6 | 1 | 2 | 3 | 4 | 7 | 14 | 21 | ||||
rinse group |
19 | female | 2.95 | 6 | 6 | 6 | 0 | 0 | 0 | 0 | 0 | - | - |
20 | female | 2.84 | 2 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | - | - | |
21 | female | 2.77 | 2 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | - | - | |
mean | 3.3 | 3.3 | 3.3 | 0 | 0 | 0 | 0.0 | 0.0 | - | - | |||
I.A.O.I | 3 .3 | ||||||||||||
no-rinsed group |
22 | female | 2.89 | 4 | 4 | 4 | 0 | 0 | 0 | 0 | 0 | - | - |
23 | female | 2.94 | 4 | 4 | 4 | 0 | 0 | 0 | 0 | 0 | - | - | |
24 | female | 2.86 | 4 | 4 | 2 | 0 | 0 | 0 | 0 | 0 | - | - | |
25 | female | 2.88 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - | - | |
26 | female | 2.89 | 4 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | - | - | |
27 | female | 2.94 | 4 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | - | - | |
mean | 3.3 | 3.3 | 1.7 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | - | - | |||
I.A.O.I | 3.3 |
body weight: at the final quarantine
Classification according to Kay & Calandra:
sample | group | I.A.O.I. | class |
100%(w/w) (50% a.i.) |
rinse | 13.3 | Minimally irritating |
no-rinse | 47.7 | Severely irritating | |
30% (w/v) (15% a.i.) |
rinse | 10.7 | Mildly irritating |
no-rinse | 11.0 | Mildly irritating | |
3% (w/v) (1.5% a.i.) |
rinse | 3.3 | Minimally irritating |
no-rinse | 3.3 | Minimally irritating |
CONCLUSION:
The undiluted test substance (50% AS) has to be classified as inducing severe damage to the eyes (R41) according to the criteria of EU Directive 67/548/EEC and as inducing irreversible effects on the eye (Eye Dam. 1) according to the criteria of Regulation (EC) No 1272/2008 due to a lack of reversibility of corneal effects.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information 50% AS Criteria used for interpretation of results: EU
- Conclusions:
- CLP: Eye Dam. 1, H318
DSD: Xi, R 41
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