Registration Dossier
Registration Dossier
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EC number: 213-268-0 | CAS number: 933-48-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1949
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data from handbook or collection of data, important study details and confidence interval given, considered reliable.
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-finding toxicity data, list III
- Author:
- Smyth H.F. ; Carpenter C.P.; Weil C.S.
- Year:
- 1 949
- Bibliographic source:
- The Journal of Industrial Hygiene and Toxicolology, 31(1), 60-62
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: see Principles of method if other than guideline
- Principles of method if other than guideline:
- Method: other: For details not reported in this publication see previous publications in J. Ind. Hyg. Toxicol. 26, 269-273 (1944) and J. Ind. Hyg. Toxicol. 30, 63-68 (1948).
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- cis-3,5,5-trimethylcyclohexan-1-ol
- EC Number:
- 213-268-0
- EC Name:
- cis-3,5,5-trimethylcyclohexan-1-ol
- Cas Number:
- 933-48-2
- Molecular formula:
- C9H18O
- IUPAC Name:
- (1R,5R)-3,3,5-trimethylcyclohexan-1-ol
- Details on test material:
- Test substance: 3,3,5-Trimethylcyclohexanol, no further data; no further information about the isomeric ratio
Constituent 1
Test animals
- Species:
- rabbit
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: none (i.e. undiluted test substance)
- Doses:
- four dosages in a geometrical series
- No. of animals per sex per dose:
- 5
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 2 430 mg/kg bw
Any other information on results incl. tables
LD50 reported as 2.8 ml/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- A dermal study with rabbits applying the test substance in four doses yields a LD50 reported as 2.8 ml/kg bw. The study was taken as key study for 3,3,5-trimethylcyclohexanole.
- Executive summary:
A LD50 was reported for acute dermal toxicity as 2.8 ml/kg bw for the test substance in rabbits. The study was taken as key study for 3,3,5-trimethylcyclohexanol.
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