Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
19 May 1987 to 24 May 1987
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
GLP compliance:
yes
Type of method:
slow-stirring method
Partition coefficient type:
octanol-water
Analytical method:
other: Liquid Scintillation Counting
Key result
Type:
log Pow
Partition coefficient:
3.1
Temp.:
25 °C
Remarks on result:
other: no pH has been reported

Table 1: Determination of test substance partition coefficient

Test System

Conc (µg/mL)

DPM/mL in octanol

DPM/mL in water

P

Log P

1-A

4.70

261079

201

1299

3.1

1-B

4.70

264545

200

1323

3.1

.1-A

.470

25545

21

1216

3.1

.1-B

.470

26227

22

1140

3.1

 

X = 1244

X = 3.1

 

SD = 83.4

 

 

Table 2: 14C-Mass accountability of the test substance

Test System

Conc (µg/mL)

Total DMP applied

Total DPM in octanol

Total DPM in water

Total DPM in water and octanol

% of DMP applied

1-A

4.70

1294528

1266233

10050

1276283

98.6

1-B

4.70

1328740

1283043

10000

1293043

97.3

.1-A

.470

120896

123893

1050

124943

103

.1-B

.470

124776

127201

1150

128351

103

 

X = 100

 

SD = 3.0
Conclusions:
The octanol-water partition coefficient (Log Pow) of the test substance at 25 °C was 3.1.
Executive summary:

The octanol-water partition coefficient (Log Pow) of the test substance was conducted with 14C-test substance in accordance with OECD TG 123 and in compliance with GLP. The octanol-water partition coefficient (Log Pow) of test substance at approximately 25 °C was 3.1.

Description of key information

Log Pow = 3.1 at 25 °C, OECD 123, radiolabelling combined with slow-stirring method, Craner 1987.

Key value for chemical safety assessment

Log Kow (Log Pow):
3.1
at the temperature of:
25 °C

Additional information