Registration Dossier
Registration Dossier
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EC number: 435-080-1 | CAS number: 1070-64-0 6,8-DICHLORETHYLCAPRYLAT; ETHYL-6,8 DICHLORO OCTANOATE
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15. Sept 1998 to 25. Sept 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Ethyl 6,8-dichlorooctanoate
- EC Number:
- 435-080-1
- EC Name:
- Ethyl 6,8-dichlorooctanoate
- Cas Number:
- 1070-64-0
- Molecular formula:
- C10H18Cl2O2
- IUPAC Name:
- ethyl 6,8-dichlorooctanoate
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Batch Ds02-01
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- 0.1 ml test substance
- Duration of treatment / exposure:
- 72 hours
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The following mean scores were calculated for each animal from the individual examinations
Cornea: 0.0 (24h); 0.0 (48h); 0.0 (72h)
Iris: 0.0 (24h); 0.0 (48h); 0.0 (72h)
Conjunctivae, redness: 0.0 (24h); 0.0 (48h); 0.0 (72h)
Conjunctivae, chemosis: 0.0 (24h); 0.0 (48h); 0.0 (72h) - Executive summary:
The following mean scores were calculated for each animal from the individual examinations
Cornea: 0.0 (24h); 0.0 (48h); 0.0 (72h)
Iris: 0.0 (24h); 0.0 (48h); 0.0 (72h)
Conjunctivae, redness: 0.0 (24h); 0.0 (48h); 0.0 (72h)
Conjunctivae, chemosis: 0.0 (24h); 0.0 (48h); 0.0 (72h)
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